ID F2L4K3_THEU7 Unreviewed; 651 AA.
AC F2L4K3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase {ECO:0000313|EMBL:AEA12181.1};
GN OrderedLocusNames=TUZN_0690 {ECO:0000313|EMBL:AEA12181.1};
OS Thermoproteus uzoniensis (strain 768-20).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Thermoproteus.
OX NCBI_TaxID=999630 {ECO:0000313|EMBL:AEA12181.1, ECO:0000313|Proteomes:UP000008138};
RN [1] {ECO:0000313|EMBL:AEA12181.1, ECO:0000313|Proteomes:UP000008138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=768-20 {ECO:0000313|EMBL:AEA12181.1,
RC ECO:0000313|Proteomes:UP000008138};
RX PubMed=21478349; DOI=10.1128/JB.00409-11;
RA Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I.,
RA Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.;
RT "Complete genome sequence of the thermoacidophilic crenarchaeon
RT Thermoproteus uzoniensis 768-20.";
RL J. Bacteriol. 193:3156-3157(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=768-20;
RA Mardanov A.V., Gumerov V.M., Beletsky A.V., Prokofeva M.I.,
RA Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.;
RT "Complete genome sequence of the thermoacidophilic crenarchaeon
RT Thermoproteus uzoniensis 768-20.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP002590; AEA12181.1; -; Genomic_DNA.
DR AlphaFoldDB; F2L4K3; -.
DR STRING; 999630.TUZN_0690; -.
DR KEGG; tuz:TUZN_0690; -.
DR eggNOG; arCOG00249; Archaea.
DR HOGENOM; CLU_010448_2_1_2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000008138; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 1..174
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 177..271
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 294..385
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 651 AA; 71415 MW; 363C06FC129DB9E9 CRC64;
MGHGIAELFA IAGYEVALVD VAEDFLKRAL QNIEWSLKKF AEKGQIKEDV QTILGRIRPI
VNDVCKAVEG AEIMVEAVIE EIETKKKVFA EADRCAPPNA ILATNTSSLP ITEISEAVKP
ERRPLVVGMH FFNPPPLMPL VEIIKGKYTS DEAVKKVAEY AAQLGKQTVV VNRDVPGFIV
NRILARVNDA ACWIVARGEA DIIAVDSALR YRVGLPMGAF LLMDYTGIDV ICFIGDAMAK
RGFKMHPCHL ITEKCQQKKY GVKTGEGFYK YPAPGKFQWP DIPKEPGERL DVVALLAPAI
NEAAYLVREG IATKEDVDKA VRLGLNWPKG PLELADEFGI DAVVKALEAW RSKTGFEEFA
PDPLLVQMAQ SGKLGRKSGE GFYTYVKAEE RRMETIIVRY EPPIAWIILN RPERLNAINA
KMVEELSAAL DEISRTDFEK VRAVVITGVG RAFSAGADIT GFVGTTPLLA YKLSRGLHEL
TEKIERLDRP VICALNGYTL GGGLELALAC DLRIASETAV LGQPEVNLGL FPGGGGTQRL
TRLVGLAKAK EIIFTGDNIS ARDAERIGLV NKVVPPERLE QEARALALKL AEKPPIALAM
AKYAINYGYE APLWAALDLE AAHFGVVFST EDLYEGVSAF LQKRKPQYKG K
//
