ID F2LI38_BURGS Unreviewed; 4423 AA.
AC F2LI38;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Polyketide synthase, type I {ECO:0000313|EMBL:AEA62704.1};
GN OrderedLocusNames=bgla_2g02270 {ECO:0000313|EMBL:AEA62704.1};
OS Burkholderia gladioli (strain BSR3).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=999541 {ECO:0000313|EMBL:AEA62704.1, ECO:0000313|Proteomes:UP000008316};
RN [1] {ECO:0000313|EMBL:AEA62704.1, ECO:0000313|Proteomes:UP000008316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSR3 {ECO:0000313|EMBL:AEA62704.1,
RC ECO:0000313|Proteomes:UP000008316};
RX PubMed=21478339; DOI=10.1128/JB.00420-11;
RA Seo Y.S., Lim J., Choi B.S., Kim H., Goo E., Lee B., Lim J.S., Choi I.Y.,
RA Moon J.S., Kim J., Hwang I.;
RT "Complete genome sequence of Burkholderia gladioli BSR3.";
RL J. Bacteriol. 193:3149-3149(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; CP002600; AEA62704.1; -; Genomic_DNA.
DR RefSeq; WP_013689036.1; NC_015376.1.
DR STRING; 999541.bgla_2g02270; -.
DR KEGG; bgd:bgla_2g02270; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_58_6_4; -.
DR Proteomes; UP000008316; Chromosome 2.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR024320; LPG_synthase_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF09924; LPG_synthase_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS51186; GNAT; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 447..646
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 672..757
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 790..1213
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2179..2255
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3111..3541
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3870..4302
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 2271..2309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4423 AA; 471036 MW; 1E3138B9815FB4BB CRC64;
MNGLREQVGA AYVAVPILLA LRRRHGGEAL ARLDRDGMAA LREWLARFAP AAGEGASNST
WDMAALVDAC FAKHAGLADL LSDLLEPYGV EPDRAAFLDV RFRACLNRLS RRLLLESPSG
LPPELRLGEA VLVPFLAAAA RSNAAWPRDA AAWRALADAF GADLRHLLDA SGLLDGLEPD
VLRAEIEGVV AFREPLLQAT RYLSILSEQD AEAGAPGNDH HCALPGELAG DAVAECEAAV
LARFAVAAAL RPRYLALVGE VAWALAERLA DAISRQDQRL GIAASEAPRI VCVPAAFGAA
CEAGVSAGER ADAARAAWRA ELGRLDIAAA DAVDRIDALL PVCLLDGAAD QAAIHQLGGL
LALGARAALV LARHGAPCAV ESLDGTPCTG LVPRMLRLLG LAAGGDAEAF LIEMAAHGLY
ARTPPLAYAH AACRRHATLG EFEARDYRIR AAVPEDLGAL LALEAACWPA ELRMPEATLA
ARLGRHAAGQ FVLDLAQPSG GYLPVGVIYS QRIASVAALH EIDADRVDSL HVAGAPVVQL
LAVNVDPACQ ARRLGDELLE FMLQRCAALP EVQSLVAVTL CRDFHKHPAL SIEAYLALRN
ASGVLADPIL RFHELHGARI ERPMPGYRPR DARNAGFGVL VSYDLAHRER NELGLAAAAS
SIDEDGAAAG KQDRSSRAID AGALHAFIED SVRRIVGEGG ELAYARDLPL MQLGLDSVGL
LEFGEALARY CGTTLVPTFL FRHNTPAAIV AHFESAARDA TVPLAAPRGR ASQADKPASA
DVAAPRAIAP DAIAIVGMAC RLPGGLDTPE AFWNALQAGT CVVGERPGER WRWPGEIDPR
GRHRGIDRGG FLDDIACFDA GLFRLSPKEV ATMDPQQRIL LELAWQALES AGYSADAVAG
SRTGVYVGAS GSDYRLLLEA AGIGVEAHVA TGASMAVIAN RISYSFDLRG PSIQVDTACS
SSLVALHQAA QALRAGECEQ ALVGGINVIC HPGNTIAYYK AGMLSPDGLC KTLDDSADGY
VRSEGAVMLM LRRLDQALRD GDPIHAVLRG SACNHGGLTG GLTVPHPDRQ ADLLRAAWAA
AGVTADQIGY LEMHGTGTRL GDPIEVRGLI DAFGTRDAAG DSCGIGSVKS NLGHLEAAAG
LAGVLKTVLG LAHREIPPSL HVSRLNTQIT LSGTPFVVVD TPRPWPMRDG VPRLAGVSSF
GSGGANAHVV LEAGVTRAEA ATAGDVLVLL GARSREQLIE YAGCLLAYCE RHAPAAADVA
YTLQRRQPMP YRLAFVADSV ETIARRLRAF VAGAAEPGLL VGAGSPDTAL ADFVNRNPDV
QQVLAGWMRE RRLEQLARCW VDGARITNWT ALHDARPACL PLPGHPFARE RHWFAAPSAP
SVVPVPSAAG GYSGKLSLTP DAAFAASAGS SDVAFQVRLD AEASYLADHR LDERAILPGV
VHFELAHAAL AALPGAAPSV LELRDLAWLQ PLEVSAASTL TVRLLADEPA GTRHYEACSG
APGTASIHAR ATIPETAGAI AEPLDLAALR ARFDLAGQAS HAEACHRCFE RMGFRYGPAH
RGLVELAWGE DPAQPSELLA RIELPACVAG SREQFRLPPA LLDAAVQAGM ALAIGRRALA
DSPACVPFSL DRLIAAGPCP ARAWAWVRRP AGTRASIASV DLDLCDEDGR VWASLRGLAF
RPLRASATPA ASRAVLAEPA VSTRLFRPRW RARPIETAQA PVRDDAAGFA PWLLLCGFER
EAAARRDLAA WRDALPDTSI VAIDAEGATP AERFADLAGR VFEQVRELAR EGKAGVALQL
LLPADGPASV FAALAGLVRS ARLEQPSWSA QVLSIDAAAG TAEALAWVRE SRADAADRAR
YRREIGQAGP AVRESLVFEP LEPSPALANP LPDERWRPWK EGGVYLITGG AGELGLAFAR
EIAAQLRSAT IVLAGRSAAD AVLAAKLDAI GRRDGLVVRH RQLDVGDAAA VRALVESLRR
EHGHLSGVIH AAGLTRDTLL ARQSREDFDA VLRPKVAGAE ALYAATADIG LDFLVSFSSI
VGVTGNLGQV GYGAGNAFLD ACAESHADRR EARHGRVLSI GWPLWRDGGM GRQPSVAAHF
ERAFGLVPMA TEYGIAAFYQ ALASDAAHVV VGHGDAGWTP ERAAASLLAS RPRVARQADA
GLGAARTEAG PGPVLDEAAR RRAVLAYLVG RIAAVLGHAP ERLDIHAPFA SYGMDSILAL
DTTRAIEAEL GSLSKTLFFE HENVQQLADH LVDEHAERLA AHGWFAAPAP SSAAGSTPAA
RPAATVDAGH PPGAILPDPR HSPPADDGAR RYRRVDKARL SAEPRLAEAV ARADGGPAVK
GIALLEIWPE LFVDTEAGAY CHLLVEGGIA FATRYTGEAR HRQALFTALL EACRQRGDEF
GYLDLSAGRK PDLEAGCGLL AAPVGVVQTI ESIGAFSLAG GRMRRLRYMV DRFRKAGTCR
VVEYREPDPA VAREIRHVIC AWSDAKKVVN NVDVVLGEMA AGRLQERYRV FLTYLGEVLQ
NVIMITPDGD GYLMDQEYYL AEMPLGGTEY AVSEILATLA AEGRERFSLG LTWGLFDTGE
GSSDPEGDAF LAGTRTQLRA ILERGAANRQ YKSKYGTKDH AVYLYRRPGK PETVIAGCLS
QFYRKGLTHR AVREMAAAAA AADAALPVSS PAPTAKPAQS TQVRDACDVF DATRVDPATL
RLDLISDSWA HVDYPHMRER ATRLDLAGGA AAADEAARSL AALFGFEHCL PTTSGRSAEQ
LLFRTLRGEP RRVPQNLLFE STLHNLVRQG FEAVELPDPR ALDADSRELF RGGIDLAGLD
RELQGAGATI AMVALELANN ASGGYPVSLA QIRATAEACR RHAVPLVLDV TRILKNAELI
RRHEPGQARR GLWEIVREIA DHADAVVGSL CKDFGLAAGG LLAVRDARQF TRAAGIARLE
GGLPGPAELR RIAAACADRA DLAREIGRQI DGVAVLHREL ERLAIPVLQP GAAHCVLLRA
DRFAATGSAA SRDALLRQLA QDYGLRGGMH HVGNLRDSHL NHCVRFALPL GLDLSRVAQA
LPAVLAAARE AREYPLEDLL HAARDATEAR PARARAASPA DPADPAADAY ADAIAIVGLA
GRYPGAPTLD AFWQNLAAGR RSISEIPAER WDWRDHYEPD PDAAVAAGKS YSKWGGFLDG
FDEFDPLFFQ IAPREAEYID PQERLFLEAC WHALEDAGYP PGAFTRAERA RIGVFGGITK
QGFNLYGAGQ AQPYQSTSLA TLVNRVSHCL DFNGPAMAFD SHCASALVAI HEACHYLRRE
PLGIAIAGAV NLNLHPSSYQ QLAKLQVLAT GDASTAFASG GLGYVPGEGV GAVVLKSYRR
ALADGDPIHG LIRGSAVNQN GRMNRFGMPS QKQQEAVLRA ALERSGVDPR SIAYIEASAQ
GSAVGDAIEM AALTRVFGAR ERAGGRYRIG SVKPNVGHGE AVSGMAQLSK VLLAFRHRRL
PPTVVSGERN PDIDFAALPF ELDAELADWE PLRIGAEAVP RRAGITSTGA SGLNVHLVVE
EYQFAVPAPR ATAEAGPRVF VLSARDRARL DDYARAWLAF LDTAAGREAS EQPEALAWTL
QAGREAMPCR LAVVARDGRE LAARLARWLE TGAADARELF HGELQAPARR RGRAVSGAGE
AIELARAWVE GAEIDWAARH EGAAPRRLAG LPTYPFQRRR FWPGPAASSQ RARAADERAA
VSPSSRADAG EAVAIDADAD ARLAAAFLPR FGKLVAEVFQ VPADELELDR PLEDYGINSF
LIKVLNVRFS EIFGRLSSTL LFEHRSAGQL GRHFLVAHRD ACAAWAAVEV EHRAVPEQAA
AAPSATAPAA AHGAAPAAAS ARARGPLAWD EPIAIIGVSG RYPQAPDLDQ FWDNLRSGRD
SITEIPADRW PLEDFYEADR ERAIGTNRSY GKWGGFIDGF AEFDPLFFNL SPREASNMDP
QERIFLQACW QALEDAAYTR ARIAHQHHGR LGVFAGITRS EFSLYGAERV KHGKAPFTSF
CSLVNRVSYF LDANGPSMPV DTMCSSSLVA VHEACEKLRH GECEVALAGG VNLALHPYMY
VSLSAQRMLS SDGRCKTFGL GGNGYVPGEG VGVIVLKPLS RALADGDRIH AMIRASCVNH
GGKTNGYTVP NPVAQRNVVR GALDRAGIDA RSLSYIEAHG TGTELGDPIE ITGLTGAFRH
DTDERGFCAI GSVKTNIGHL EAASGIAGLT KVLLQMRYGQ LVPSLHAEQL NPGIDFTASP
FVVNRETRPW ARPVVDGREY PRLAGVSSFG AGGSNAHVIL EEAPRVMAAA APAVATSGPA
STPAGGPVLI VLSAKKPEQL RRYASELLTR LRDPEYRRRA EADGLRSLAC TLQLGREAME
ERLAVVADSV LALETRLSQF VDGKADIENL HVSRVGRSPH HVN
//
