ID F2NKQ0_MARHT Unreviewed; 615 AA.
AC F2NKQ0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN OrderedLocusNames=Marky_0049 {ECO:0000313|EMBL:AEB10813.1};
OS Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Marinithermus.
OX NCBI_TaxID=869210 {ECO:0000313|EMBL:AEB10813.1, ECO:0000313|Proteomes:UP000007030};
RN [1] {ECO:0000313|EMBL:AEB10813.1, ECO:0000313|Proteomes:UP000007030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14884 / JCM 11576 / T1 {ECO:0000313|Proteomes:UP000007030};
RX PubMed=22675595; DOI=10.4056/sigs.2435521;
RA Copeland A., Gu W., Yasawong M., Lapidus A., Lucas S., Deshpande S.,
RA Pagani I., Tapia R., Cheng J.F., Goodwin L.A., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Pan C., Brambilla E.M., Rohde M., Tindall B.J., Sikorski J.,
RA Goker M., Detter J.C., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Woyke T.;
RT "Complete genome sequence of the aerobic, heterotroph Marinithermus
RT hydrothermalis type strain (T1(T)) from a deep-sea hydrothermal vent
RT chimney.";
RL Stand. Genomic Sci. 6:21-30(2012).
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DR EMBL; CP002630; AEB10813.1; -; Genomic_DNA.
DR AlphaFoldDB; F2NKQ0; -.
DR STRING; 869210.Marky_0049; -.
DR KEGG; mhd:Marky_0049; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG1520; Bacteria.
DR HOGENOM; CLU_020359_0_0_0; -.
DR OrthoDB; 9788659at2; -.
DR Proteomes; UP000007030; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF13570; PQQ_3; 2.
DR SMART; SM00564; PQQ; 5.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:AEB10813.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000007030};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:AEB10813.1};
KW Transferase {ECO:0000313|EMBL:AEB10813.1}.
FT DOMAIN 8..263
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 615 AA; 67753 MW; AC719FBF79B52A07 CRC64;
MKRLAGRYRL LEPLGEGGMA EVWKAHDDRV DRDVAVKLLY PHVHPAERQR FAREIQALSR
LNHPGVVHIY DLGEEEGRTF FVMELVEGGS FDRLGPYEHG PEGLRLLEAA LRVLEALEYL
HGQGVIHRDL TPRNILTTRE GHPKVMDFGL AYLTDATRHF TRTGYTLGTP QYMAPEQAKG
APLTPQADLY SFGAVLYRTL TGRPPFEGEN DQAILYQHVY EPPPPPQAQN PAIPDALARF
VTRLLAKTPT ERPANAALAH AQLARIIQTL KEELYGTARA GANRSGHYPD GPPDPERLQL
AGSLKLGGEV AWPAEPVAHE GILALGTSAH ELLLIRTHPL RLEARLPAKD EVTAPALLAP
DRVAYASWDG AFRVWDPERR AEHHAYETRA EITASPLSAA GLTYVPSRDG HLYALDLQGA
VRWAFEAGGH LTAGPTLYRG LLFIASENGW MYALDPPTGQ LRYKVETGPI HAHLPAADGV
LILPTWAGEV HGFDPLRREV LWTYDVEGEL WGSPAVGHGR VYVGGWSGVL YALDLRTGDE
VWRAELGRLT ASLSLAQNHL YAATEDGRLI AFRAATGEVV WQAEGMGPIQ AAPFPYRDAL
YVADLSGTLY VFREG
//
