ID F2PWV7_TRIEC Unreviewed; 314 AA.
AC F2PWV7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Pyruvate dehydrogenase complex component Pdx1 {ECO:0000313|EMBL:EGE06375.1};
GN ORFNames=TEQG_05378 {ECO:0000313|EMBL:EGE06375.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
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DR EMBL; DS995747; EGE06375.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PWV7; -.
DR VEuPathDB; FungiDB:TEQG_05378; -.
DR eggNOG; KOG0557; Eukaryota.
DR HOGENOM; CLU_056413_0_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR045257; E2/Pdx1.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF82; PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:EGE06375.1}.
FT DOMAIN 38..78
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 110..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 314 AA; 33990 MW; C0C498F79B0A91BF CRC64;
MANLSALARR LPLRQTSNGY SSVRCVQTAA QQPNLSYPLY PSVAQLLKQN NIPSNDVSKI
TATGPNGRIL KGDVLSYLGT IAASYPADLA SQLAKNSRLD LSNIKIAAPQ APSPAAPAPQ
GEQIQVREET AGSRSEEAAE SVFETKIAVP VSFSKLISVR RRIQSSVGVE IPLATFVSRA
ADIANENLPV KPSEKQRSSA LFDEILGHRP SASAQMAFSR GDYLPEIVSP SEFYSSSGES
QQSLRKSTDD IIDVLTGRSP PSKRNVTRTV EAEEDRNTSI FSLTIPEHEE ARAMAFLEKM
QVLLEEEPAQ LLAL
//
