ID F2PYS6_TRIEC Unreviewed; 1179 AA.
AC F2PYS6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=TEQG_06033 {ECO:0000313|EMBL:EGE07044.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995755; EGE07044.1; -; Genomic_DNA.
DR AlphaFoldDB; F2PYS6; -.
DR VEuPathDB; FungiDB:TEQG_06033; -.
DR eggNOG; KOG0926; Eukaryota.
DR HOGENOM; CLU_001832_0_4_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EGE07044.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 345..522
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 545..791
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..654
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 131772 MW; 8A3C8A858DB4E7FF CRC64;
MPKFVPRQRK HKARDRNNQP KQPQDTNVAE VAPVSKKEKE EKRQKLREEL RAQQSKISGK
KQKRLDKYID TKLRKDENLT LIKKLAKSKI DTSQLQSSRS LARSNKPLSK KPQLPSGSKK
GPSSEIFESE SSGSDEDLPS SRSHINARGD GDIPANTAVG SGLKRPLEIG DDGRPIIKRR
KRMPKTKPIE IQEPAWEGFD SEPESSADKE QGDSEADSYR GSGESEEDSV SGSENEENSS
SESEVETEKK IKPRQSAFKS WAVQQINEAA GFTPDNIAAP TLPPQNAKNF KPRDTTEEEE
PLPQELRVTN GDTSRKSFAI QINRPEHIQA ARLNLPVVGE EQKIMEAIHN NPCVVIWGAT
GSGKTTQLPQ FLFEAGYGSP DSPNPGMIGI TQPRRVAAVS MAKRVSEELS QYSDRVSYQI
RFDTSVTSKT AIKFMTDGVL IREVAQDFSL SKYSTIIIDE AHERSVNTDL LIGMVSRIVD
LRKTMSTENP SIKPLKLVIM SATLRTSDFL RNPNLFRSGT PPLVQVEGRQ FPVTIHFSRR
THRDYVEEAF RKVCRGHRKL PPGGFLVFLT GQSEIKDLSK RLKAALKSTQ PSGRSQAKVQ
IRPSEASVEA DDIDFGRGGE SATAFDGDDD FDSDIDIRGT DEDEEDDEFD EEEGAVDSKT
SVHVLPLYSQ LPTTEQLRIF EPVPEGSRLI VLATNVAETS LTIPGIRYVF DCGRSKEKQY
DLSTGVQSFP IGWISKASAS QRAGRAGRTG PGHCYRLYSS AVYEDSFAEH TEPEILRTPI
EGVVLQMKHM GLHHIINFPF PTPPDRTGLA KAERLLRNLS ALSLDGQVTD AGRHLTLFPL
SPRFGKMLHI GHQHDCMPYT IALVSALSVS EVFIQENQLD LTKDKSAGDD EEEDKMYTNA
DRLEDDAREQ RRKDYQRAQR IFSKHDEKSD AMKFLTAVCA YAYAPNGEKF CSEMFLRPNA
MKEASQLRRQ ISNLVRINNP NLLAQFEPRL REPSEKQIRA LKQITAAGFI DQIAIRADAA
PVRPDMPRKP RRAIDVPYLT LFPSRDHYSS ELEDRAVYIH PSSVLAKLSL NELPQYVVYS
HLQQSTPSHI GDSPKVRMFP LTPVSGLQLS ALAQGTPLIE YGKPIGKIES LGGSPERREC
WVVPSLVGES GSTGWPLPAK KVIQVRDKKH GWIIDRFIQ
//
