ID F2R4B0_STRVP Unreviewed; 293 AA.
AC F2R4B0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Transcriptional regulator, HxlR family {ECO:0000313|EMBL:CCA53387.1};
GN OrderedLocusNames=SVEN_0099 {ECO:0000313|EMBL:CCA53387.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA53387.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA53387.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 {ECO:0000313|EMBL:CCA53387.1};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
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DR EMBL; FR845719; CCA53387.1; -; Genomic_DNA.
DR RefSeq; WP_015031307.1; NZ_JABVZO010000054.1.
DR AlphaFoldDB; F2R4B0; -.
DR STRING; 953739.SVEN_0099; -.
DR GeneID; 69862327; -.
DR KEGG; sve:SVEN_0099; -.
DR PATRIC; fig|953739.5.peg.3535; -.
DR eggNOG; COG1225; Bacteria.
DR eggNOG; COG1733; Bacteria.
DR HOGENOM; CLU_993619_0_0_11; -.
DR OrthoDB; 9792527at2; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd03017; PRX_BCP; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR002577; HTH_HxlR.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33204; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR PANTHER; PTHR33204:SF26; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR Pfam; PF01638; HxlR; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51118; HTH_HXLR; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..109
FT /note="HTH hxlR-type"
FT /evidence="ECO:0000259|PROSITE:PS51118"
FT DOMAIN 127..289
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 293 AA; 32087 MW; 9325CAA24677EF0F CRC64;
MARAVPDRDA ACAIAQAAAV VGDWWSLLLV RETARGQHRF DELQRELEIS RKVLTERLNH
LVDSGVLDKV PYQEGPVRFE YRLSDAGRAL LPVLVSMQDW ADRWLLGDGS LTASADERSA
EAHRVHDLPG ARLPRLTLPA HTGTGLDPVD ADAGATVLFC YPATGRPGPL PDDWLDIPGT
AGCTLENRLF REAYERFTAA GVAVRGVSTQ RPDEQRAFAA AEEIPFPLLS DMDNALSAAL
RLPTFRAGQA LRLKRAVLVV DRERTVRHVQ FPVTDIPAAV ETAWREGSAV ASE
//
