ID F2R5Z8_STRVP Unreviewed; 1337 AA.
AC F2R5Z8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=SVEN_0372 {ECO:0000313|EMBL:CCA53659.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA53659.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA53659.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FR845719; CCA53659.1; -; Genomic_DNA.
DR STRING; 953739.SVEN_0372; -.
DR KEGG; sve:SVEN_0372; -.
DR PATRIC; fig|953739.5.peg.5940; -.
DR eggNOG; COG0745; Bacteria.
DR eggNOG; COG1511; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG4251; Bacteria.
DR HOGENOM; CLU_000445_3_0_11; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 6.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 4.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 5.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 6.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 2.
DR PROSITE; PS50885; HAMP; 6.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CCA53659.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 25..71
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 111..163
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 203..255
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 295..347
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 387..439
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 479..531
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 783..1014
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1217..1334
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 711..773
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1267
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1337 AA; 142423 MW; 36629B48273A28EB CRC64;
MSDMTTEGSS VRVRPGPAAV GEPELRQLLA GLTAVRDGDF GTRLPDEADG LMGEISLVFN
GMVDQLSLFT SEVTRVAREV GTEGTLGGQA AVPGVSGTWA DLTDSVNAMA GNLTTQVRDI
AQVATAVARG DLSQKIDVDA HGEILELKNT INTMVDQLSS FADEVTRMAR DVGTEGILGG
QADVKGASGT WRDLTDSVNS MAGNLTAQVR AIAHVATAVA NGDLSKKVDV DARGEILELK
TTINTMVDQL SAFADEVTRV AREVGTEGNL GGQATVRGAS GTWKDLTDNV NVMASNLTGQ
VRSIAQVATS VARGDLSRRI TVEAKGEVAA LADTINTMVD TLSAFADEVT RVAREVGTEG
RLGGQARVPN VAGTWKDLTD NVNSMANNLT GQVRNIAQVT TAVANGDLSK KIDVDARGEI
LELKTTINTM VDQLSSFAAE VTRVAREVGS EGRLGGQAEV EGVSGTWKRL TENVNELAGN
LTRQVRAIAE VASAVAEGDL TRSITVEASG EVAELKDNIN AMVGSLRETT RANQEQDWLK
SSLARISALM QGHRDLAVVA ELVMDELTPL VAAQYGAFYL AEEGTDGVEL GLVGSYGRPA
GDQGRDRFRL GESLVGQAAR SRRTIAAENV PADYVTISSG LGSTSRGSLV VLPVVVEDQV
LGVIELMSFT PFTSVHRDFL EQLMETVGVN LSTIVANART DELLDESQRL AGELRSRTEE
LQVRQEELQR SNAELEEKAA LLATQNRDIE AKNLQIEQAR QELEDRAQQL ALASTYKSEF
LANMSHELRT PLNSLLILAQ LLAQNPTRNL TAKQVEYAGI IHSAGSDLLQ LINDILDLSK
VEAGKMDFNP ERVPLRRLLD YVEATFRPLT TQKSLAFSVT TAAGVPVDLV TDDSRLRQVL
RNLLSNAVKF TEHGSVELRI EPASDAELPV PVHRGGPVVA FRVTDTGIGI APENLEAIFG
AFQQADGTTN RKYGGTGLGL SISREIAFLL GGALTVTSVA GEGSTFTLYL PVTRTDVTEK
PAARQLEAAE VSVPALEAAP APAAGPGTAT ARPTRRLLVI EERPRGLLAV VAENAVTQLS
ADGGHAERTD IELIAVVGPQ EAAAALADQP FHCVVLDLDM ADGDALRFLA AMDGDEALRT
VPVLAHNNRR LPADEEGALQ ELARRRPLEL LSSLDELRER IALHLSAEQP GDVVPLVRGD
HWAPAPQAID TTLHGRTVLV VDDDARNLYA LSGILELHGV TVLHAENGRK GIETLLANPA
VSLVLMDVMM PEMDGYTATA RIRELSQYAD LPVIAVTAKA MPGDREKSLA SGASDYVTKP
VDADELIACI GRWLNDG
//
