ID F2RF62_STRVP Unreviewed; 319 AA.
AC F2RF62;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=UmuC domain-containing protein {ECO:0000259|PROSITE:PS50173};
GN OrderedLocusNames=SVEN_1355 {ECO:0000313|EMBL:CCA54642.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA54642.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA54642.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 {ECO:0000313|EMBL:CCA54642.1};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR845719; CCA54642.1; -; Genomic_DNA.
DR RefSeq; WP_015032560.1; NZ_JABVZO010000010.1.
DR AlphaFoldDB; F2RF62; -.
DR STRING; 953739.SVEN_1355; -.
DR GeneID; 69863539; -.
DR KEGG; sve:SVEN_1355; -.
DR PATRIC; fig|953739.5.peg.3423; -.
DR eggNOG; COG0389; Bacteria.
DR HOGENOM; CLU_012348_1_0_11; -.
DR OrthoDB; 4317601at2; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006854}.
FT DOMAIN 11..118
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 319 AA; 34142 MW; 1C9EBF6F4E9446D0 CRC64;
MILCVRFRIE PMYEALFPQL VDLLGEFTPV VEAAPPDGAL ADVRGALRYF DRSAAELASV
IRVRALALYG VDCVIGAGPN PMLARMAASE ARPGVTLVVE DPEAFLRDRP VVALDGVGRA
TARTLCGYGL DSVGRVAAAP LAVLQRLVGA KTGRELWERA RGVDRTPVVP HAASRSLAAE
RAFPRDETDR TEQRRALLSL TEELGARLRA EGQVCRGLAV TVRYADRTTT TRSRTLPEPT
AHSAALTALA YAVHDSFGLQ RARVRGIALR AEGLTGAEGA AHQLSLDPAD EKARRIEAVA
DRARARFGPR AVLPGSLAA
//
