ID F2RJI7_STRVP Unreviewed; 258 AA.
AC F2RJI7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ADP-ribose pyrophosphatase {ECO:0000313|EMBL:CCA55197.1};
DE EC=3.6.1.13 {ECO:0000313|EMBL:CCA55197.1};
GN OrderedLocusNames=SVEN_1910 {ECO:0000313|EMBL:CCA55197.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA55197.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA55197.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; FR845719; CCA55197.1; -; Genomic_DNA.
DR AlphaFoldDB; F2RJI7; -.
DR STRING; 953739.SVEN_1910; -.
DR KEGG; sve:SVEN_1910; -.
DR PATRIC; fig|953739.5.peg.4064; -.
DR eggNOG; COG0494; Bacteria.
DR HOGENOM; CLU_062658_5_2_11; -.
DR OrthoDB; 177518at2; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43046; GDP-MANNOSE MANNOSYL HYDROLASE; 1.
DR PANTHER; PTHR43046:SF14; MUTT_NUDIX FAMILY PROTEIN; 1.
DR Pfam; PF00392; GntR; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CCA55197.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854}.
FT DOMAIN 2..70
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT DOMAIN 117..245
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 258 AA; 28974 MW; AE434B2238520A83 CRC64;
MGPKTQRVYE TIRSWIESGR YGPGDKLPSE RTLTGELEIG RTALRQVLAR LANEHFIKAH
DRSSYRVLGS ASVPTPAEME PWKIHGSRHV YENPWVTLDL VDVEPPGVER FEHHVVRLFR
VAITAVIDDQ DRVLMLWRYR FVPEQWGWEL PGGIVDAGED AAATAARETE EETGWRPGPV
KHVVSYQPMI GMVDSPHEIF VARGAEKVSE PTDAEEAGEI AWIPLDDIPR LMSEGKLMGS
GTLVALLHIL ATRTRGDR
//
