ID   F2S3T5_TRIT1            Unreviewed;       579 AA.
AC   F2S3T5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:EGD98234.1};
GN   ORFNames=TESG_05615 {ECO:0000313|EMBL:EGD98234.1};
OS   Trichophyton tonsurans (strain CBS 112818) (Scalp ringworm fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=647933;
RN   [1] {ECO:0000313|EMBL:EGD98234.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 112818 {ECO:0000313|EMBL:EGD98234.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Henn M., Martinez D., Young S.K., Zeng Q., Gargeya S., Haas B.,
RA   Alvarado L., Berlin A., Chapman S., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Larson L., Mehta T., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., White T.C.,
RA   Abdel-Rahman S., Graser Y., Gurr S.J., Kohler G., Martinez-Rossi N.,
RA   Oliver B.C., Rossi A., Shelest E., Summerbell R., Lander E., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Trichophyton tonsurans strain CBS 112818.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; GG698509; EGD98234.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2S3T5; -.
DR   HOGENOM; CLU_034665_0_0_1; -.
DR   OrthoDB; 47357at2759; -.
DR   Proteomes; UP000009172; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00431; cysteine_hydrolases; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR43540:SF1; ISOCHORISMATASE HYDROLASE; 1.
DR   PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          8..351
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   579 AA;  64822 MW;  35D6DAD2EC75A1AD CRC64;
     MHGTDVLRVG VAIGHGTGPE LAAVFENVLR ELASRYSLRI EFVRSDRIYH SYNSLPLSDG
     SQNAILDICD ETVNDITHYQ QFCEREASRG LKVIFRTAIS AQSLYAVRQQ LESVKVECFD
     RGTSSLLVIR DQAQGFYTGT NKLESDQKSV SRVCEFRKEV FQHILEFSLE RAREKWGHDL
     RGIKTIFLVY KFHLFDGLLL SWAKELTEEF GIKVEFIQPD TMNRNMIAFG VNRCLMVAGN
     EYADIMQTIF LERFNVRVQE TSCSENVYLK PVLNRLSEYQ TTHGSADDIT GKGIVNPSAT
     IRAAAAILER FGGCTGIDAE VDETLNILQQ NKSVTPDQGG NLTTNAFVDL FLQTLPSPSV
     GTPTGSEFSQ SSSLADDPTD ICPAPDFAAA FMKKATAVVV VDFQNDFISL GNPENMSSIT
     DALVRVLAFS RSHAQEIVFI QHLGDQRYQN ASWRHRNRVQ SRKELCVEGT RGADLSPALS
     PARSEHIFTK KAQFDAFQSP EFEKYISEKG IEHIILVGLY ADICIDATAK AAFQRGLWTT
     VVQDCTTALH LKDEDILGYM QKVYGTRVVE SEKLLRMHA
//