ID   F2SG30_TRIRC            Unreviewed;       733 AA.
AC   F2SG30;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Type I phosphodiesterase/nucleotide pyrophosphatase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TERG_02155 {ECO:0000313|EMBL:EGD85886.1};
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85886.1, ECO:0000313|Proteomes:UP000008864};
RN   [1] {ECO:0000313|Proteomes:UP000008864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
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DR   EMBL; GG700649; EGD85886.1; -; Genomic_DNA.
DR   RefSeq; XP_003237435.1; XM_003237387.1.
DR   AlphaFoldDB; F2SG30; -.
DR   STRING; 559305.F2SG30; -.
DR   GeneID; 10378813; -.
DR   eggNOG; KOG2645; Eukaryota.
DR   HOGENOM; CLU_017594_4_0_1; -.
DR   InParanoid; F2SG30; -.
DR   OMA; DGHKFGP; -.
DR   OrthoDB; 1366859at2759; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd16018; Enpp; 1.
DR   Gene3D; 3.30.1360.180; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151:SF120; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        195..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..702
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   733 AA;  81891 MW;  C4E44E1316BB8D0A CRC64;
     MSADRPTSQR RPSSSPYLLS PGGYDEDATT IRALSDQESD SEDDQLMEAS RSTLDLVQHD
     RTVLEEEEER ERLLIRAKSS PTDGLRRIFG ANPHDNGSFS VKIGKRDRSR RRRRELAAMT
     SDRRRRRSSA QSNNDTMNLG EDDELMYEME EGVCKAIDSD DDSRSVSTIS SIFSDLDPRD
     IESRGYCGSD SSCRVVSLIT FAILILFSLL YLGAYKASSG YRTSHHQPPN TISNGTSLFL
     PTTILISLDG FRADFLTRGL TPTLNSFIAN GISPKYMLPS FPSVTFPNHF TLVTGLYPES
     HGIVGNTFWD PELKDDFYYT KPEKSMQPKW WTAEPIWATA EKQGVKTAIH MWPGSEAHIM
     GIEPTFLDKY NGSEALPRKV DRILELIDLP GEKDADIPPT IMQRRPQLIA AYVPNVDAAG
     HTFGPNSTEI RTTIANADKM LASILQGLEA RNLTNVVNIV VVSDHGMATT SVDRLVQLED
     LVDLNLVERI DGWPLRGLVP KRKEDIQLLF EQAKNHTAFM GFDDYLEIYT RETMPERYHF
     SKSNRIAPLW VIPKTGWAIV ERPDFDVKLA QKEGKAYHPM GIHGYDHEHP LMRAIFVARG
     PSFPHKANSR VQEFQNIEVY NIICDSLRVQ PRPNNGTLRL PLKPVGLHSD GKSPPIENLD
     DQDPPKSTSS KTPISTRPPV PHPTAITGNA GIPPPPPPKA TQQSQGRPSS IIDRIIDKVK
     GWASDLLGFV GLG
//