ID F2SH62_TRIRC Unreviewed; 312 AA.
AC F2SH62;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=TERG_01645 {ECO:0000313|EMBL:EGD85371.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85371.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; GG700649; EGD85371.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SH62; -.
DR STRING; 559305.F2SH62; -.
DR VEuPathDB; FungiDB:TERG_01645; -.
DR eggNOG; KOG0757; Eukaryota.
DR HOGENOM; CLU_015166_6_0_1; -.
DR InParanoid; F2SH62; -.
DR OrthoDB; 4772at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR049562; SLC25A33/36-like.
DR PANTHER; PTHR45829; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR PANTHER; PTHR45829:SF4; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000488}.
FT REPEAT 28..138
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 151..245
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 312 AA; 34065 MW; 69C697B1B5A4834B CRC64;
MAHSSKELIQ PTIISSPQLK PKPDNDFVKS LSHLVAGATG GAITAVLTSP LDVLRTRLQS
DFYRPVLSST ASPKPMQQPA FQASRPMLGH IRETFQILFS IYHVEGWRGL FRGLGPNLTG
VVPASAIKYY TYGNVKRIIG ESQIFGPNSE NAMGCHIISA VTAGITTGTL TSPIWVIKTR
LQLDKSQSAN SPQAAPRRYK NSFDCARQVL RQEGPRGLYR GLSASYLGSL ETTFHLALYE
QLKMLIVRMR SNQDEPCART TGNKTLGDRL SGLLGMGGAA ALSKFLSSII AYPHEVSIDI
TFGETRQEVQ VN
//
