ID F2SKD0_TRIRC Unreviewed; 588 AA.
AC F2SKD0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN ORFNames=TERG_03483 {ECO:0000313|EMBL:EGD87233.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD87233.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; GG700650; EGD87233.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SKD0; -.
DR STRING; 559305.F2SKD0; -.
DR VEuPathDB; FungiDB:TERG_03483; -.
DR eggNOG; KOG3717; Eukaryota.
DR HOGENOM; CLU_013513_5_1_1; -.
DR InParanoid; F2SKD0; -.
DR OMA; MAMSSYE; -.
DR OrthoDB; 1429709at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF115; CARNITINE O-ACETYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 11..565
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 302
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 588 AA; 67030 MW; 59E8A47D0B2888B6 CRC64;
MLRFEDSLPK LPVPTLEETG RRYLKSVHPL LSAEEYKKTE KAVSDFIKPG GEGEVLQKRL
IARSEDPKTD NWLYEWWNQS AYLAYRDPVV PYVSYFYSYR DDRQRRDPAK RAAAITSSVL
EFKRQVDDGS LEPEYLRKEP MAMSSYQYMF NCCRIPAEGE DYAQQYPAKG NEHIIVMRKN
QMFKVPTTVN GQQLNTSEFQ KQFETIIKKA ERVPAVGALT SANRDFWTAA RKKLLAASPA
NEEALKTIES SSFFVCLDDA SPVTLEERAH VYWHGDGANR WYDKPLNFVI NENGTAGFLG
EHSMMDGTPT HRLNDYVSQL IFSNALDYSN PSIRSNLPEP QPINFELNPA ILEDISTATR
DFEALINKHE LRVQAFQAYG KGLIKKFKCS PDAYVQMLIQ LAYFKMYGKN RPTYESASTR
KYKLGRTETT RSVSDDSVAF CKAQADPSVS REELVKLFRA AVAAHSKYTA EASVGKGVDR
HLFGLKKLIR DGEEVPSLFK DPTYAYSGSW FLSTSQLSSE YFNGYGWSQV IDEGFGIAYM
INENSLQFNI VCKKIGAERM SFYLNEAACE VRDMLMPDLL KESEKAKL
//
