ID F2SWX0_TRIRC Unreviewed; 638 AA.
AC F2SWX0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN ORFNames=TERG_07067 {ECO:0000313|EMBL:EGD90842.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD90842.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU365057}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC ECO:0000256|RuleBase:RU365057}.
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DR EMBL; GG700656; EGD90842.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SWX0; -.
DR STRING; 559305.F2SWX0; -.
DR VEuPathDB; FungiDB:TERG_07067; -.
DR eggNOG; KOG2229; Eukaryota.
DR HOGENOM; CLU_009161_2_1_1; -.
DR InParanoid; F2SWX0; -.
DR OMA; AMYKTYK; -.
DR OrthoDB; 5482564at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365057};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU365057};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT DOMAIN 13..327
FT /note="SDA1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08158"
FT DOMAIN 436..562
FT /note="SDA1 middle"
FT /evidence="ECO:0000259|Pfam:PF05285"
FT DOMAIN 586..631
FT /note="SDA1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21638"
FT REGION 393..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71614 MW; 26E0B9D64AA5A889 CRC64;
MSRLPRNILT LIYSLLQTLF PILVSTPSKT LRAFLFQKIV SDLRSANAKT TNHKLNRTIQ
TVLFNLVVAD RSSSKALWSV KITRELWKRQ IWTESKAVEI MKEAALADNE KVIIGGVRFF
LGGDKEREEL EDESSDDDVI DVGKVKHQAT INKGSKKRAK AIEKAKAMVK KKEKKKNAPH
PLNFSALHLL HDPQGFAENL FQKHLQNTKA KLNLEQRLLV LQLVSRLVGL HKLTIIQLYS
YFLKYLTPKQ PSVTSFLASL AQSCHSLVPP DTLEPLIQKI ANEFVSEGSA AEVASAGLNA
IREICVRQPL AMNDTLLQDL VMYRKSKDKG VMMAAKGLLS LYREVGAEKL KRRDRGKDAA
MGLKIGERKS QRYGEEEIGE IEGLELLEKW KEEERRKNRR ENGLPSDGES DEDEENENDW
AAWNMEEDDS DDSGGWIDVQ SDVDIVFSDS EDDEPTAKKA KTDEDATKAG DDKKTEESEA
KKISRLATTR ILTPADLAKL AELRAAASVN ALLPENKRKR LLQQAAANRH ADDPLTAAEI
EGLAALSAGK QTREEKIAHV NETKTDRSEF KSKLARKKET KEKLGKSSTN KEKARKKNFM
MTLGKAKAKG KRSLVETRAT LRAHHERNKR GGKRGNQG
//
