ID F2SXF8_TRIRC Unreviewed; 842 AA.
AC F2SXF8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB {ECO:0000256|ARBA:ARBA00015819};
DE AltName: Full=Sulfur controller B {ECO:0000256|ARBA:ARBA00032113};
DE AltName: Full=Sulfur metabolite repression control protein B {ECO:0000256|ARBA:ARBA00030034};
GN ORFNames=TERG_07253 {ECO:0000313|EMBL:EGD91030.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD91030.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC involved in the regulation of sulfur metabolite repression, probably by
CC mediating the inactivation or degradation of the metR transcription
CC factor. {ECO:0000256|ARBA:ARBA00002730}.
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC {ECO:0000256|ARBA:ARBA00011725}.
CC -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC {ECO:0000256|ARBA:ARBA00007968}.
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DR EMBL; GG700656; EGD91030.1; -; Genomic_DNA.
DR RefSeq; XP_003232405.1; XM_003232357.1.
DR AlphaFoldDB; F2SXF8; -.
DR STRING; 559305.F2SXF8; -.
DR GeneID; 10372087; -.
DR VEuPathDB; FungiDB:TERG_07253; -.
DR eggNOG; KOG0281; Eukaryota.
DR HOGENOM; CLU_000288_103_0_1; -.
DR InParanoid; F2SXF8; -.
DR OMA; HSKGIAC; -.
DR OrthoDB; 337075at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF723; E3 UBIQUITIN LIGASE COMPLEX SCF SUBUNIT SCONB-RELATED; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 91..137
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 317..350
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 358..401
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 491..530
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 531..570
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 156..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 92927 MW; 1BCCB3DCEC658E6A CRC64;
MGREAGASFG LQPRDYSVLP AKSSCKIDEG YSDETKSVQE NESVQDSLEL PAWILARSEA
DRAELAYTLL RTLRTSSITG VIERLTPLLH MDPVRKLPPE ITAEIFSYLD PTTLLTASLA
SKPWRSRILD SRLWRGLYIK EGWRLNMSSI REFHRQSSEI AKQQQGRKSR NRHSESESGQ
PQLKRRALAC DRAGAGPPEV VIGRMPTDTE GDHEMHDAVT VEPNSPMEIS SPTRLAARLA
EKCNVPHSLD PSMHSPGFDS LFTDDRSPLP YSSAAVWSRN GPTLNWAYLY KQRQKLEENW
RHGRFTNFQL PHPDAPWESH RERVYVIQFA GKWLVSGSRD KTVRVWDLES LRLRGQPLVG
HTKSVLCLQF DASPEEDVIM SGSGDRSVIV WRFSTGEKIH ELPNAHLDSV LNLRFDKRYL
VTCSKDRTIK IFNRNALLPT DADYPRVAKG TGPRYPDYII DTAATPPSTL EAQMANQQIK
PLAPYSLLIT LDGHRAAVNA IQIDKDEIVS GSGDRLIKVW SIHSGTCLKT ILGHNKGIAC
IQFDNQRIVS GSNDDTVRIY DHTSGAEVAC LKGHSGLVRT VQAGFGDPPG SEETMRLEAL
AVDQEYFEAR RRGDIDENPV TTRRSHRPPN TGSRLPQDVM ALGAKIPPGG GGSNWARIVS
GSYDESIIIW MRDKEGKWII GQRLNQAEAI RAARAAAAAA AARTQANDLS STNEILQAGP
ASTETMQGPH HANNLEIGAA ASAAHNPLPP QQPTDQAADT NLPPAPALQH QAQGPHVPPN
PLPANIDVAG HQALIPPTAG ILKIQFDARK LICASQDTRI IGWDFAAGEK KLEEACQFFE
GL
//
