ID F2SXI4_TRIRC Unreviewed; 618 AA.
AC F2SXI4;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Inhibitor of growth protein N-terminal histone-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TERG_07277 {ECO:0000313|EMBL:EGD91056.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD91056.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ING family. {ECO:0000256|ARBA:ARBA00010210}.
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DR EMBL; GG700656; EGD91056.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SXI4; -.
DR STRING; 559305.F2SXI4; -.
DR VEuPathDB; FungiDB:TERG_07277; -.
DR eggNOG; KOG1973; Eukaryota.
DR HOGENOM; CLU_006204_0_1_1; -.
DR InParanoid; F2SXI4; -.
DR OMA; WAYSNRN; -.
DR OrthoDB; 3140066at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15505; PHD_ING; 1.
DR Gene3D; 6.10.140.1740; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028651; ING_fam.
DR InterPro; IPR024610; ING_N_histone-binding.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10333; INHIBITOR OF GROWTH PROTEIN; 1.
DR PANTHER; PTHR10333:SF42; INHIBITOR OF GROWTH PROTEIN 3; 1.
DR Pfam; PF12998; ING; 1.
DR SMART; SM01408; ING; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 71..181
FT /note="Inhibitor of growth protein N-terminal histone-
FT binding"
FT /evidence="ECO:0000259|SMART:SM01408"
FT DOMAIN 564..607
FT /note="Zinc finger PHD-type"
FT /evidence="ECO:0000259|SMART:SM00249"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 564
FT /note="Histone H3K4me3 binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR628651-50"
FT SITE 575
FT /note="Histone H3K4me3 binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR628651-50"
FT SITE 579
FT /note="Histone H3K4me3 binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR628651-50"
FT SITE 587
FT /note="Histone H3K4me3 binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR628651-50"
SQ SEQUENCE 618 AA; 65832 MW; CB45EA9A1FF83B7B CRC64;
MASSSMPTGG NASNIRQTAR QTRTNPSRQS KTAGRTSLIG GLAGGPSSLG GGHGANGSVH
GNSVPAGIYP GITHFSDAID ALPREFRRHN SLLNEVDGKA WALEEQLSKL LTTATKLISV
DYDAPRPKQV DVTPTRQVFQ SIRSTLGDLL GTIDEKNHVA RNANATLQRD VSRLDAIYPH
VQREVSDEAR LGSLTHWAYI NKPTPKTSAS AVNERPRRDT AGANSHRAAH GDADNEPKKE
PVRRQRRTQA EIEADEARGI TVRRGKPGPK SRTADNQSSE QALTAGGAPG IVTAKRRKVE
HTQSMAATAM ERSASTATNA GGRAGSKESP APDAVKKRTR APNVNSAARK RTNTVSSNAG
SPAVAGALNV SQLGHTSNSP APASSLRAQS RPQQNQTPAS RQRPSSSASN RNPKKDLLDA
RPPSAKGAAS PRIDTLASRS NGDSIRNSPK TATLELKHED ASSMGPVGTS SHMHDGKADY
SNLPELNTGV STKRSSKNST PVSTTYAESQ QRSRPSRTGD GPKRSHKKTG SISTARQMAL
SAAADEAADE PRNAEGDDPM EPRYCYCNEV SFGEMVACDN PNCPREWFHL SCVGLTKPPS
KSGEYFSFFN ITRVYGHG
//
