ID F2SZD8_TRIRC Unreviewed; 579 AA.
AC F2SZD8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=TERG_07909 {ECO:0000313|EMBL:EGD91690.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD91690.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; GG700658; EGD91690.1; -; Genomic_DNA.
DR RefSeq; XP_003231609.1; XM_003231561.1.
DR AlphaFoldDB; F2SZD8; -.
DR STRING; 559305.F2SZD8; -.
DR GeneID; 10371286; -.
DR eggNOG; KOG0785; Eukaryota.
DR HOGENOM; CLU_034665_0_0_1; -.
DR InParanoid; F2SZD8; -.
DR OMA; FQRGLWT; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00431; cysteine_hydrolases; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR43540:SF1; ISOCHORISMATASE HYDROLASE; 1.
DR PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864}.
FT DOMAIN 8..351
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 579 AA; 64694 MW; 44307060F4EFDDCD CRC64;
MHGTDALRVG VAIGHGTGPE LAVVFENVLQ ELASRYSLRI EFVRSDRIYH SYNSLPLSDE
SQNAILDICD ETVNDITHYQ QFCEREANRG LKVIFRTAIS AQSLYAVRQQ LEAVKVECFD
RGTSSLLVIR DQAQGFYTGT NKLESDQKSV SRVCEFRKEV FQHIIAFSLE RAREKWGDDL
GGIKTIFLVY KFHLFDGLLL SWAKELTEEF GIKVEFIQPD TMNRNMIAFG VSRCLMVAGN
EYADIMQTIF LERFNMRVQE TSCSENVYLK PALNRLSEYQ TTHGSADDIT GKGIVNPSAT
IRAAAAILER FGGCTGIDAE VDETLNVLQQ NKSVTPDQGG NLTTNAFVDL FLQTLPSPSV
GTPTGSEFSQ PSSLADDPAD ICPAPDFAAA FMKKGTAVVV VDFQNDFISL GNPETMSCIT
HALVRVLAFS RSHEQEIIFI QHLGDQRYQN ASWRHRNRVQ SRKELCVEGT RGADLSPALS
PARGEHIFTK KAQFDAFQSP EFEKYISEKG IEHIILVGLY ADICIDATAK AAFQRGLWTT
VVQDCTTALH LKDEDILGYM QKVYGTRVVE SEKLLRMHA
//
