ID F2T3E8_AJEDA Unreviewed; 4070 AA.
AC F2T3E8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143};
GN ORFNames=BDDG_00887 {ECO:0000313|EMBL:EGE77950.2};
OS Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE77950.2};
RN [1] {ECO:0000313|EMBL:EGE77950.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE77950.2};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188}.
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DR EMBL; GG749408; EGE77950.2; -; Genomic_DNA.
DR HOGENOM; CLU_000050_0_2_1; -.
DR Proteomes; UP000007802; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 6.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 2.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 3854..4066
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 3222..3702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3714..3755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3256..3273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3274..3325
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3333..3381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3391..3418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3548..3569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3570..3585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3589..3606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3613..3628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3661..3681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3718..3744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4070 AA; 455839 MW; 0A15D0658AF529C1 CRC64;
MNPATDAGKR DLAPGLRSRF TEIYVNSPDT EIDDLITLID AYLGSLTVAD KKASIALARL
YLDTKKLNAD NKLTDGAGQK PHFSIRTLVR SLIYVRNQAH IYGLRRAMYE GFCMSFLTLL
SKESELQIIP LLDQHIFGSL KNSRSVLSQT PKPPNDGATY VQFKHYWMRQ GAFPIESQSH
YIITPFIERN LMNLVRASST RRFPILLQGP TSSGKTSMVE YLAKISGNRF VRINNHEHTD
LQEYLGSYVS GEDGSLRYQE GILVEALRNG YWIVLDELNL APTDVLEALN RLLDDNRELF
LPESQEVVHP HPNFMLFATQ NPAGLYGGRK VLSRAFRNRF LELHFDDIPE DELEFILKER
SQIPPSFCAR IVAVYRKLSL LRQSSRLFEQ RNSFATLRDL FRWAQRRADD REQLAVNGFM
LLAERVRNPQ ERAAVKEVVE EVMRVKLDET TIYSSTRLDA RLQQLSATAP TGIIWTQAMR
RVFILVSQAI EHNEPVLLVG ETGCGKTQIC QAIAEIYGKE LFTINAHVNL ETGDIIGAQR
PLRNRSAIEG QLLADLSSVL NSIDTYDESS DSSIDELTRA FSALQTEALD MCEPGLVNRI
RENMTRAKAL FEWSNGSLIT AMETGQHFLL DEISLADDSV LERLNSVLES HRSLLLAEKG
PIDSLVVARD GFQFLATMNP GGDYGKRELS AALRNRLTEI WVPQLSEAED ILPILSAKLL
SPISNAPSSM LTFAKWFKET FQATSSGSIS IRDLLAWVDF VNQCKELDDV TAMVHGAALV
YIDTLGANPS AMLASGASNL KHDRVRCLER LGKIFGFDAA SIYYQAATIS MEENIMRIGP
FVLEMNTHSE NDPTFSMDAP TTIANTLRIA RGLQSAKPIL LEGSPGVGKT TLVAALAQSL
GKPLTRINLS DQTDLTDLFG SDVPVEGGDM GNFSWSDAPF LRAMQTGGWV LLDEMNLASQ
SVLEGLNSCL DHRQQVYVAE LDQTFKRHPN FVLFAAQNPH HQGGGRKGLP ASFVNRFTVV
YADSFSDNDL KMICQRLSPL APEKEIQQLV EFVSSLNFKV TNERRLGTVG GPWEINLRDI
SRWLKLLEST PIRVSPSQFL DVVISQRFRT PSDRTLVASL YEDVFGSTPE IKSYFHNLSV
SQYQVGLGVL QRDPLMQYFN DPHMKILAGD LPIMESLILC IEQGWPSILV GASGCGKTAI
LRKLAAFSGS KVVELALNAD TDTMDLIGGF EQVDNDRHLL SFLDELCQFL QAQIVSTHTA
TKQTDVDSEL VQLYQTVKSR TPELETISDA LHRISLKELH PNFTEFYQRS KTLLKSSSGG
KTIGFEWTEG IFIQSVQKGD WVVLDNANLC NPSVLDRLNS LMEPNGCLVI NEQRTGDGTA
KVVKPHPNFR LFLTMDPRYG ELSRAMRNRA IEICFPPRAD EAMPKAGGIF YTSESLIYRI
RWGQDLSCYR KESDRLQDEL EVSLDHLAPH DFRSLQQSSA TSIDIWTTNS AADTKRSTTI
YQTFDRYHAF LHHDTLPPLK DILCNGSWNE QKFSSFRQSV EPLHPLINEP RIVACIVPES
RALLAKLTKL QEIQFNVWHF HQVLSQVRGS VSNKKPSEMN RLERSMASNT IPALMKESTQ
PVALYLSNCI QALSETIQNI DAELLCSVDV CAMVSSILEL CWDIFNVVQA NDFDEGVFQT
YLQIGQSLYS RFKDVQLDLV RVLFESLNNF RANWGLTTGQ SMQRMWDRWR PATPIDPAHL
KSMVDLQYVA AQFDQITLKT NLPFTQLNQF RHSLVQAQIS MLQGADPGGL IQDLQHVIDD
FETRMLDSDS VSAPYFSMEF EALSQYRDFI DIRKLDTATT NSALSNVLQL LAGRPASPHD
MSTLENPVPE LLSRISRFSG FQNMSRKPLA LRGTISLSLI VKLGSLGNVP LKGMNLLHSE
LDLIANGLCS STGQIAHNQF DILQSRLGEL LRELLHCHED LIDPTSLASA VSYLGSLGRE
LPSGYSKIQT LRLNLRDNSE KHHYFNEFAS RSFNKILSSL VGGENGAAKY LQLGAACIHL
AMACLQLFVP NKPFDPSLGL VVQQQQYTQR VQEKTRKLDA LKAFELSFSG QESSLRIRMI
NGELQLLGAV PPSPPVIRPK PSQSGELQGE FANILNSVLS SNPDVILRSL QDSGSSDSGN
AVNQQGKLLQ KNIQQICLRL TTNYKAYGDV VIPIVRFLEI LHLGVELVQC AEHRSHLGQS
FMQAMGQVTP LMSARRVSLV ELQQPSSRLS NAEKIDLGLQ RLSVLRVFQN TDPETLSAAE
NRQLLRDIFE DFSILWKQQL EVDQNKHSQK SSLYRYRGSF EGDQEVDADE FSQLFPTFDG
PIENDLESRT LPQLDVKTIS MQLSSVLDNL FSRLDKESTL KKLLVDSTKL LGSNIAKHLG
DIPTADPKSH LLGAILFLDE VKTSKQPTSY NFYSDPNLVE VKKLADLVAA IRVRFKELQN
SWPEHSTLSD VIHCCSEIFQ FRHQEPLAKF ITKAEKLHSF IYEWQTVASK AFSAAQCYDN
LTALLINWRR IELSTWARLL DIEDEKCSED ASAWWFVAYD VIIAAPLRLV QDGQPLTEHS
VELIATLERF ICSTPMGQYK FRLQLVAKFK MLLHLYATDF PPLEQLSGAI DNLLHHYLPF
VSIFEKSLGD GRQALERDIQ QTIQLASWKD VNITALRESA RRSHNKLFRV VKKYRSLLGQ
SSEGLFMKGL SCPPDTIESL PDKCIALPDR VSSTALRVCR ENVHAWGQRP IRFTDPDGAV
KSMQRVYENS LTGLLAHEEL DAFMRDIIDT IAEFKSRTPK TLTEDNQHDV QHLKGQKRRF
YAEKLKDLRF MGIRSNVGTT ILESQQSVAA VLSTTRPLTA HVDSVHIKSA DSYFHRFLDL
VPRVRISSHE YSEDLSNVEV ARSAGFIEGL LHWALKQRET LSWRMDNFIA LESTMQQMRN
VSDLSSSLLY SNSYLPSSRR DLRGTLRWLS TILGVCGSTL QIHRNFAGID SSEVLGALDD
WKTRLNTLLI SIENLKTLPP GLSTSTHENL FSSVQTLVSD IRSDVLKRID EHPELTFALE
QILPWTELCT KSSMPETNGQ IRISLQEFDS ALLTTMDKIF VVMQKLSSSL STAPSSKDTP
AWLVKTEQVI SKACAELHMV DIAGAINSVL AQIQHISTTD STSLTVVGAA ISVVLPIAEQ
YKSICTDVLH RYSALHREMC KMSYLLAKSF NQIASEGFCT PLESSGEQGK SDKLESGTGL
GDGEGAEDIS KDVQDDEDLS DLAQEKQQMD GDKEDKEGED DAVNMDHEDL EADRSDFEDE
KDAEDGKGSD QEEEEDMDID EETGSVDGLD ASAVDEKMWD GTNDQEQKDT ENEQGKGEPE
SEDKTAAPTE KNEKVDQDKD GEESENEGSE PPDHEGEAVG REDMDTTDPH AKEEPVLDLP
EDMELDGQDD KDKEGSDLDD DLGGLSDDNN STWEGEPDAP EQPNDDLDLD SQHQVEDEAE
TAEEATEEVV NGQEDAEGPK EEPETKTAEE EEEEREGLLE MERTDNQADS ENIAPSEEVS
GGLGVDQDQN REKGDSGEAT QEQGSKDQAD EQKPQTGSAD QGEDGKEATN ASGGRDDGKL
EDSQTQAFKK LGDILEQWHR RQRQIKETSD NQDTSQNENQ DANMEDADFE HLADDQDVAD
TQALGQANEE QAKSLDQSNA VESDMKPEEG EFLPDAGEPQ NLPAEQSLED QMDLDQKPGL
PENNNTSRSF VAGDRSMETE PTNQNGQKEE SREMEDMDTH LSALHVTSEL APLSSPEEAR
RLWSHYESIT HDLSLSLTEQ LRLILAPTLA TKLRGDFRTG KRLNIKRIIP YIASQYKRDK
IWMRRSVPSK RSYQIMIAVD DSKSMLESGS GQLAFETLAL VAKSLSMLEA GDLCVVSFGD
EDHVRVAHEF GKPFSSEAGV QIFQQFSYKQ TGTNVRKLIS DSIALFREAK AKRSRSSGSG
DLWQLELIIS DGICEDHETI RRLVRQAQEE RIMIVFIIVD AVKGNSILDL TQASFEPDGS
GTGEMKLKMK RYLEGFPFAY YLVVRDVQEL PAILSLALKQ WFAEVVDVAA
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