ID F2T5G8_AJEDA Unreviewed; 1497 AA.
AC F2T5G8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Peroxisomal ATPase PEX6 {ECO:0000256|ARBA:ARBA00034811};
DE AltName: Full=Peroxin-6 {ECO:0000256|ARBA:ARBA00034920};
GN ORFNames=BDDG_01330 {ECO:0000313|EMBL:EGE78393.2};
OS Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE78393.2};
RN [1] {ECO:0000313|EMBL:EGE78393.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE78393.2};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Peroxisome membrane
CC {ECO:0000256|ARBA:ARBA00034691}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00034691}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00034691}.
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DR EMBL; GG749409; EGE78393.2; -; Genomic_DNA.
DR HOGENOM; CLU_000688_0_2_1; -.
DR Proteomes; UP000007802; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR CDD; cd19527; RecA-like_PEX6_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047533; RecA-like_PEX6_r2.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF9; PEROXISOME ASSEMBLY FACTOR 2; 1.
DR Pfam; PF00004; AAA; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Peroxisome biogenesis {ECO:0000256|ARBA:ARBA00022593}.
FT DOMAIN 789..916
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1066..1208
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1497 AA; 161787 MW; 291A3C5141EC2759 CRC64;
METISRGSTD LKRRRRREGL RRRQANKNAV SGRLVLDHHA RGDVGTLSDD LATYLFLGSS
IEALAESQEV RYIAISPWSP HNLPVEDLPW TFLPVRLQSP AKSQASPISH STVHFPAFAG
SIQSFVQALE TLDPTRNSIS SQRAIEIHVL DVVPLYLDTV YVTVERHLLS TVDEIQNKFG
GGFGPGTQGI NGLWAKGRSP ENLIKKSSKE TKEAAAEREE RLIGVIREAI SAQRILHAGD
LLPLPLPSHP ITYAPPPPAR ISFCEPVSQG LVKPTTRIVL VQTKSQQQSR ISKGLPSPGQ
ALLKEVAEDE ADDTSNEQFY SAAEEKSNGT DMESTSPPDE SDTDTSAQSY SDGSDDSLDD
MISLAAPELP QQPSGTMSAM TSATPRPGDK RFDVHTPGSM LSSFTSATAR TGRYAGKTFR
AEGLMERISN DILHPKPRES EDSDSFVYVD IHTLAKIGCF SGDWVRIEAA EEPQLNMLSS
LKFDGLNRLT ENAADDMTWR AVRVYGLPGL TSPRPRYSRR STISQMPSHG LTPTVLVPPI
LLNNLENPKY LKLSPILVHG SHHSSSRPGI VQSKSSSPKT PPVAKEVTLL KISTPLSMDR
SLQPVLFAGL KRHFESKQRL VKSGDLIGIS VDEGLGKTIF SSTKGPEPGE DDDVTAQLGF
SPDSQSRPQN ALRKVGVAWF RVSQVVSAPV EGLENGSEDE RWGGVAVIDT SSTRMVQAGS
VISTIPGTLY NGWEYWLGVK PLPKTCSDIG KSRSFVTEPP TIFVPAVQKR LRELISASTS
PRAIQLGMKP VVILLTSTQR AIGKSTVARR ACAEVGIHTF TIDSYDILAE GGANGGDVKT
EAFLKARADR AFTCGANCTA LLIQHIDVLT ADRMVTAMKE IVADARVVIA TTTDVEKVSE
GIRSVFTHEL EMTAPEEKER EGILRNVIYD QGIKVSANVD LASVAVKTAA LVAGDLVDVV
ERAVAVKTLR LQKLAESATT SDERLKVTVR DIQAAGGDAA RCVTKEDFDA AVDAARKNFA
DAIGAPNIPN VGWDDVGGLT NVKDAVMETI QLPLERPELF AKGMKKRSGI LFYGPPGTGK
TLLAKAIATE FSLNFFSVKG PELLNMYIGE SEANVRRVFQ RARDARPCVV FFDELDSVAP
KRGNQGDSGG VMDRIVSQLL AELDGMSGGD ENGGGVFVIG ATNRPDLLDA ALLRPGRFDK
MLYLGVSDTH EKQVTILEAL TRKFNLHPDL SLRRIAEQLP FTYTGADLYA LCSDAMLKAI
TRKASAVDEK IKELPGGPVT TAYFFDHLAT PEDIAVMVTE EDFIAAKSEL VASVSAKELE
HFERVRRTFE SVDDAKKPRP SITAGPETSS HAPLTIGEAV NGLKPGTRLE DPTLANITNN
ANKSTASSIL PHRAKHGNKA SRSKGKNNVS GAKGKSAVVP SSLDQHSEPD EDMENGLDSP
VGNENVGDVN GTAVRGSKGK GKDTVVDGLA MATNGDEAEE DEYVIRTDHL VRSDKPS
//
