ID F2TE17_AJEDA Unreviewed; 702 AA.
AC F2TE17;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=6-phosphofructo-2-kinase {ECO:0000313|EMBL:EGE81480.1};
GN ORFNames=BDDG_04422 {ECO:0000313|EMBL:EGE81480.1};
OS Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE81480.1};
RN [1] {ECO:0000313|EMBL:EGE81480.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE81480.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG749426; EGE81480.1; -; Genomic_DNA.
DR AlphaFoldDB; F2TE17; -.
DR HOGENOM; CLU_006383_3_1_1; -.
DR Proteomes; UP000007802; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF32; 6-PHOSPHOFRUCTO-2-KINASE 1; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 2.
DR Pfam; PF00300; His_Phos_1; 2.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EGE81480.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EGE81480.1}.
FT DOMAIN 122..175
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT DOMAIN 274..451
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 78639 MW; D3AFF119565DF4A7 CRC64;
MADHLTANGR HGPSNIHHSP EPSLMPPCKT VVGRALAPEH HHHHHHHHHQ HRSLSATHAP
SQASRDGVGM ALTDTPLSTA PPSPQIGARS HSSGASTPGK HRATTLDIPG LTKSKVSPDG
RIAQRDVGSK LVIVMVGLPA RGKSYITKKL ARYLNWMQHD TKIFNVGERR RVAAGGSVPS
AGRSSIFEDE IRDSVREMSI SGSSSGRRDT EHEILPPAAI LLNGAAVESP TPQDQDGITR
DPSPMSDMPY LYPKSKPASA SISSASLSPE PAIGTMRSTG AGSIDQSAQF FDPANEQAVQ
LREQVALLTL DELLDYILEQ GGSIGILDAT NSTLKRRKAI MDRIRARAGP ELNVLFLESQ
CLDKELLESN MRLKLSGPDY RDQDPTLALE DFKKRVALYE KSYVSLGEYE EKHNMPYVQT
IDVSRKVIAH QVNGFLSSQV MYYLLNFNLS PRQIWICRHG ESLDNVAGRI GGDSPLSENG
IRYARALTRF IGEQRQLWEQ YQKSKALSTH FPPRPGDSTP PNPQYAGQNA EPRNFCIWSS
MLTRSIQTVQ FFDDEEYDVK QMRMLDELNA GKMEGMTYEE IRKQFPEEYA NRKRQKLHYR
YPGPGGEGYL DVINRLKAVI VEVERMTDNV LLVSHRSVAR VLLAYFRGLK REELADLDVP
LGVLYMLEPK PYGVEFKAYR YNPSTDWFDF MPNYELRQAS YY
//
