ID   F2TJD6_AJEDA            Unreviewed;       587 AA.
AC   F2TJD6;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=MFS transporter, AGZA family, xanthine/uracil permease {ECO:0000313|EMBL:EGE83349.1};
GN   ORFNames=BDDG_06293 {ECO:0000313|EMBL:EGE83349.1};
OS   Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE83349.1};
RN   [1] {ECO:0000313|EMBL:EGE83349.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE83349.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease.;
RA   Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
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DR   EMBL; GG749448; EGE83349.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2TJD6; -.
DR   HOGENOM; CLU_024508_3_2_1; -.
DR   Proteomes; UP000007802; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          546..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  62758 MW;  4A7B8634A6FD4AF0 CRC64;
     MKDWGAAVNR AVAGSIVGRR FRLEGSGHRH ERKGTRFLTE VRAGLTTFFA MAYIISVNSN
     ITSQSGGTCV CNDPVDPTCM GNTEYELCLN AIRRDFITGT AAIAALSSFC MGLFANMPIA
     LGPGMGLNAY FAYNVVGFRG TGPVPYRLAL TAVFVEGFVF VGLSVCGMRQ WLARAIPRSI
     KLASGAGIGL YLSLIGLTYS AGIGAITGDT ATPLTLAGCV ESEMVDGICP PGAKMRNPTF
     WVGLFCGGVF TCILLMYRVK GAIIAGILLV SIISWPRPTN VTFFPHNPKG DDSFDFFKKV
     VTFHPIKNTL IAHDWDLSNA GGQFGLAFIT FLYVDILDAT GTLYSMARYC GAINERTQDF
     EGSAIAYIVD ALSISIGSLL GLSPVTAFVE SGAGIAEGGA TGITAMVTGL CFFVSIFFAP
     IFASIPPWAT GCTLVLVGSM MTKVVSEINW SYVGDAVPAF ITLAVMPFTY SIAYGLIAGI
     MSYILLNTVA FIIEKASRGR IVPHNKNLKE PWSWRVPGGI LPAWLVRLVN GKRDFWREDI
     LDNQDYSPGT NSNTNAAETE GYAVRENKGA GVTAGSTSDS GDVQKEQ
//