ID F2TLF3_AJEDA Unreviewed; 619 AA.
AC F2TLF3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Asparagine-rich protein {ECO:0000313|EMBL:EGE84101.1};
GN ORFNames=BDDG_07046 {ECO:0000313|EMBL:EGE84101.1};
OS Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE84101.1};
RN [1] {ECO:0000313|EMBL:EGE84101.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE84101.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease.;
RA Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GG749461; EGE84101.1; -; Genomic_DNA.
DR AlphaFoldDB; F2TLF3; -.
DR HOGENOM; CLU_022834_2_0_1; -.
DR Proteomes; UP000007802; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd06133; ERI-1_3'hExo_like; 1.
DR CDD; cd12452; RRM_ARP_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 2.
DR InterPro; IPR047201; ERI-1_3'hExo-like.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034351; Nrp1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23111:SF40; RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED; 1.
DR PANTHER; PTHR23111; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 2.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 2.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 2.
DR PROSITE; PS50199; ZF_RANBP2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 253..331
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 352..381
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 428..459
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 527..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 66320 MW; 17FB8904A2A18E88 CRC64;
MAAIHAPSPK LDRYVVIHVA TTCDEHGVYV TKDSAEVIEL GWILLDSENC KELHRESVLV
KPVNTPITPL CTSLTTLTWE HVRSAGTFRD AINQFDAFAQ EHLLSKNLEF SFVTLDSWDM
RVQLPREARD KAVVLPPYLQ HSRTFDLRTE YQRWQQHHPE SLPFGPSDLA NICAALEVEP
MQSSAPIKHN LPFHLQALAP ASPRRAMEEA ITLARVLHGL IRKSQPAHEH PEILTRPMDA
RADVRAFLAE RSKVLHMSGL PHDTTQSELE SWYTQFGGRP IAFWTLRTPD QHKPTGTGFA
VFSSHEEAAE SLCMNGRALN DKAIEVSPSS SRVLDHAAEI LTPFPPSKNR PRPGDWTCPS
CGFSNFQRRT ACFRCSFPAV GTAPDPMGYG GYGYGPPSMM PPPHHMGHHG GHGHSRGMGG
NGGVVPFRAG DWKCGAEGCG YHNFAKNINC LRCGGPRSGA AVVADSAFPS PMDPPSGFGM
GPASIASTPG PGPFASSAGG FGAFGQQFGG PPSTYALPSG LGAASGPYPP MGQMSQMNQM
NAPYGSANAS HSAASFGNPA TQAAFTGADH VPQPVGASNG NFYGNDASAD PFAFLASGLG
SLTVEESRRN GAANNKSPA
//
