ID   F2TPJ5_AJEDA            Unreviewed;      1347 AA.
AC   F2TPJ5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=5-oxoprolinase (ATP-hydrolysing) {ECO:0000313|EMBL:EGE85158.1};
GN   ORFNames=BDDG_08103 {ECO:0000313|EMBL:EGE85158.1};
OS   Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE85158.1};
RN   [1] {ECO:0000313|EMBL:EGE85158.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE85158.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease.;
RA   Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; GG749485; EGE85158.1; -; Genomic_DNA.
DR   HOGENOM; CLU_002157_0_1_1; -.
DR   Proteomes; UP000007802; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
FT   DOMAIN          11..232
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          252..559
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          574..757
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          778..1314
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          1307..1347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1347 AA;  147165 MW;  A5D03825B2CDE5E0 CRC64;
     MAIPVQRRGI RIAIDRGGTF TDCVGNPGSG KLEDDIVIKL LSEDPNHYDD APLEGIRRLL
     SKFEGREIPR GEPLNTAKIE SIRMGTTVAT NALLERKGER MALVVTRGFK DCLEIGNQSR
     PKIFDLAIQR PDVLYEKVIE VDERVTLEDY TEDPIQHSTP TLPRDLSPPD AEIVRGLSSE
     AVRILRRPSE SIVKTQLQTL YNEGFRSIAV CLMHGYTFPD HEVMIGRLAR QTGFDHISLS
     HELMPMIKLV PRATSACADA YLTPTIRKYI SGFQSGFEGG LGTSSLKKEH GSKGARCEFM
     QSDGGLVDID NFSGLRAILS GPAGGVVGYA LTSYDSKTDI PVIGFDMGGT STDVSRYGSG
     RYEHVFETTT AGVTIQSPQL DINTVAAGGG SRLFYRNGLF VVGPESAGAH PGPACYRKNG
     PLTITDANLF LGRLLPEFFP KIFGPKENEG LDAYASAMLF EELTETINEE LPEDQKMTPD
     EVAYGFIQIA NESMTRPIRS LTEAKGHDTS KHRLATFGGA GGQHAVAIAE NLGIKQIFVH
     RYSSVLSAYG MALADVVDES QVPESKVWSD DGSTITELRQ KMDTLKEGAR RRLRDQGFED
     KSIVFEEYLN MRYRGTESAL MIINPKSRVA TGGSDSGSDW AYGKAFVQQH EREFGFTFPD
     RDIIIDDVRV RAIGKSFDDL GKTVDQQLEE AKPQDVGDEK KFSVSQVYFE GGRRQTPIYK
     LEDLNVNDRI HGPAILADGT QTLVITPGAT ALVIETHVVI NISTSELRDA KINLNTVDPV
     ILSIFGHRFM AIAEQMGRAL QKTSVSTNVK ERLDYSCALF DSDGGLVANA PHLPVHLGSM
     STCVRTQSKI WAGKLKPGDV IVSNHPEFGG THLPDITVIT PAFNGNKIIF YVASRAHHAD
     IGGILPGSMP PHSKELSQEG AAIKSEKLVS EGIFNEERIT HLLYHEPAQY PGCSGTRCLA
     DNINDLKAQI AANQKGINLI SMLISEYGED TVQFYMNNIQ DNAELSVRNL LKTVSQRFAG
     ADLVAVDYMD DGSPIHLKIT IDAEMGEAVF DFEGTGPEVY GNINAPEAVT YSAIIYCLRC
     LISEDIPLNQ GCLKPINVRI PKNCFLSPSD KAAVVGGNVL TSQRVTDVIL KCFQACAASQ
     GDTNNLTFGY GGNVSGEEET KGFGYYETIA GGSGAGPDWE GTSGVHTHMT NTRITDSEVF
     ERRYPVLIRE FSLRPGSGGD GQHRGGDGVI RDIEFRIPVQ VSILSERRVY HPYGLNGGKD
     GQCGLNIWVR RTPKRGQPGE WEVREINLGA KNTAKMFPGD RIVVKTPGGG GWGKVGEESK
     ARKGRDLKQA WKGGSLASRI ETQETSA
//