ID F2TWN0_SALR5 Unreviewed; 2368 AA.
AC F2TWN0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Laminin B1 {ECO:0000313|EMBL:EGD72476.1};
GN ORFNames=PTSG_00501 {ECO:0000313|EMBL:EGD72476.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL832955; EGD72476.1; -; Genomic_DNA.
DR RefSeq; XP_004999045.1; XM_004998988.1.
DR STRING; 946362.F2TWN0; -.
DR EnsemblProtists; EGD72476; EGD72476; PTSG_00501.
DR GeneID; 16067505; -.
DR KEGG; sre:PTSG_00501; -.
DR eggNOG; KOG1388; Eukaryota.
DR InParanoid; F2TWN0; -.
DR OMA; PVCQWCD; -.
DR OrthoDB; 5471913at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 4.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF21795; JAG1-like_EGF2; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF00053; Laminin_EGF; 2.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00180; EGF_Lam; 5.
DR SMART; SM00423; PSI; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2216..2237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 773..811
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 839..903
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 904..951
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 963..1077
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1075..1107
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1812..1861
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2334..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1079..1089
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1097..1106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2368 AA; 250939 MW; AA2CA38D1C52CA56 CRC64;
MAACDTTQHA ASCGHCTCNP WEVDCPLAPW ARVAADPVPV VSEHGVAAHA AVYHAQLDVL
ATFGGLTVNG PSSQTRMYNF TAQGWTTLAP AAASPAPAAR YSHAFWLDGD ALHIHGGVNA
SERTAAAYGI AHHPAHYTDD HWRLDLQSGV WRRVDARGVP PPAVAGHTAT LVGDTVYVVG
GRTADTLFSA YVHAFNVTDE AWSRIVPLAA HLGKVSDHAA VYHPQSHAII VSGGYIPGNL
RFPGRTSQVL LFSLTEPSWR VLVAHDDSRP TLAFHSAVLW GRFMVLFGGF RHSHYEDEEC
HSNDLLVFDV DCATWHPHTP ALNSPFSGRF AHAAAVRNGH MLLHSGFSGI FHTDLLITDA
STLTGRMGFS RFERASMPAR DSDVIADVFN PSVGVAASVV SVVDEANRVS VPRHTLFLAT
IVASVTGVHG FGVKSNDPDG FFGVWAAPEV AWQNATTPPQ GSRLLFVQHT SQTRGMVVYT
SVNMTAGQPY YLAFSTGARG GIRYEAKLEW KQPADAAFRI LTADDGVHQF QTRACARHAD
CSSCLYDAAC FWCDGQCRSS NDTATSTANT TTTTTTTTTS SGSSMACASA PVLSAGLCTD
CSTALTCHEC VDDAVPGCAW WRDTCVPVAA VSDNSSTTDA AACPAPCSRR EDCSACIGAD
AGATCVYCES TASCIDRATS TAVNAFGQCL SFAYSSDESS QPCANCSVHA TCDTCLNKLG
CGWCAHPDDG DVGACVSGDF DGPAEQQCPL VSANNTYVLE PARGEFYYPH CPDVDECALQ
IDDCGPNAVC RNTNASYVCE CEPGYASASV LFPGRSSAPC MPQCTNACVH GTCTAPDQCT
CDVGWAGATC DVDCGCNFNA ECTNATTFGV CPVCLHNTTG PQCGTCAPGF YGNATDPGVG
CRACECNGNG DAAKGTCDPS TGVCYCTNYA AGDSCEQCQP GFYRRNGRCY AGCRYDDRAY
NAVGWTSRVA LVEPAAGFGT HTDVRSTHTS DTSCMWLIRA PANHSIRVTF EFVSVECAYD
YVHVFDGAAP HSSKVLAMLN GELPTTTVYS YTGEVLVVLF SDISYELRGL EATYAIEECP
ALCSGHGSCD GTGRCRCDPG WSGDACAAEN CPRNCSEHMG QGTCNAARTA CVCTPGYTGR
DCSAQEQPGV WRPLLVGSAG DAGDAGGAGA AAPVGRSGHT AVLNAAGTQL WVFGGLRGNE
YLGDTWVLDL DTRVWSEFEM APSSLTPAGR HLHVSAWFDD RLFVMGGATG PATYTNDVWR
LSLDKQAWTH VSTSGDAPPA TAGHCAARVD NTLYVFGGLS QDVGLAATLY ALDLGSSVWT
RVSTFGSRPD GHFAATLVHD AARNQLILFG GRRYVSPGTL RDPVRNAVMR MFDLSTNAWR
VASTAPIFCE SASCIARSQH AAAVVGDYLV VHGGNPFLHR TQNMCHSDET LIFNIPCGKW
IADTTAAAEA AATSGSDGDM TASLVPLLRK AHQAVALPSG EVLIFGGVST SALNDVYVYR
PRAEYCAFHL SVRNCDDDPS CVWNATASAC VVASGAGLRN CTSPFTDAAA AQCTDRSRSR
GLFSQDECRA CVSHDACEYC PSTTSCAATS DAAACPQSSP VVFDSSSDAC GDCSHLMTCR
SCLSDPACTV GQGVCAERAA PATTPVDVDA VCLPSCTVHT TCGDCATQSG CVWCEGTQSC
VSSATVTTEF AFGQCFRYAG EASTCPILDC QDASECDDCL AMARCGWCAD PGLNGTGQCL
QGTLAGPGIY AFNTSSTCSG ALRSVVGEAA LALPAAFRNN DDDDDSDGTA ILARVPEDTL
NHTTWNSIDC PDVDECALGT ALCSDIAVCI NEDPRLVPGS RGYRCLCPAN YTLLDDGVTC
AAVCSTYGCV NGFCSRPDVC DCYQGWYGRN CTSNCGCNGH CTCSDTSARS ACLDNTEGPD
CERCQDGFHG AAEGNGTCLS CLQVCNGHSV HCRPNAVPLP GQENEPVCRN CSYPSRGSYC
EQCMQGHFLD PAILKSARDA GLAPLDYIEQ NASTVNSSCV PCQCNGHSSV CNSITGEECQ
CKDNTLSSAN NCDEDEYGSC YHAQCDTCMD SQSYSGVVLQ LSGDPRDGRP CFVVPSADVA
VQQQLGPGDL ITFEITPKFT NVNMRLFAEV DRALPSRVRM YVLRDANVTV DERTHQLEFG
QAPVFAEDVE RRTLFVAKYK AYRFAEDRFF VALHNTGANA TSVLFYFTQP VVSIDLVVFF
TVFFSAFFLF AGVVIGASKI HVVLSERATT IQEQTQMQTL ARRPMGKLLL AWGPPVISGD
AAVNVANAIS TGELQPTPIA SQPTRGNQSS LVTMLVELPS GTAHRNLSLA TANVRVPREG
GVRNRRWRRR RGDDDDSNNS SSISTSRL
//
