ID F2TY22_SALR5 Unreviewed; 1258 AA.
AC F2TY22;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_00984 {ECO:0000313|EMBL:EGD76281.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832956; EGD76281.1; -; Genomic_DNA.
DR RefSeq; XP_004998456.1; XM_004998399.1.
DR AlphaFoldDB; F2TY22; -.
DR STRING; 946362.F2TY22; -.
DR EnsemblProtists; EGD76281; EGD76281; PTSG_00984.
DR GeneID; 16079051; -.
DR KEGG; sre:PTSG_00984; -.
DR InParanoid; F2TY22; -.
DR OrthoDB; 5346049at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR CDD; cd09487; SAM_superfamily; 1.
DR CDD; cd00173; SH2; 5.
DR Gene3D; 3.30.505.10; SH2 domain; 6.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR19969:SF5; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF00017; SH2; 3.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00252; SH2; 6.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 6.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 77..174
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 207..251
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 565..657
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 670..762
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 809..911
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 921..1016
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1132
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1258 AA; 140632 MW; 0E7D1B826BD8CF76 CRC64;
MAMVTPVVEK DKHMVPPQDL VQPSTSTDQG REQQRDDDLA RMLKLRMTDP ELQATAQPLS
DQITDSVVDM VTLAAPWYHG RRPRHSVNFA LTPETKEAGS FAIRKVGDAV HDGFQLHLKT
DEAILERHIE VTANETVRLE GTTAEYETLS QLVAAYSDGS ESEGALPFPL LNPVRMRANT
FGNTDASTAG PAPDDDGITH AADGEPWKIA DVCDWLEDLG LSKYTPAFRD RGIDGVRLLN
IDHLDLQQMG VDPHDARAIM RNVAALKAQT VEVSSETPSW VRRTLVVKEL DGELRLFDAA
SGEEVYQLAH EIARQLNFAP PSSATTIKSS IADDEDDETE FAWVGDTKGW VRRGNSGRKL
YEGDWSVDDM CAWLQHVNLD VCVPIFKQRR LTPSRFKALD PEQQAAIGEE SGVGNALVEA
WRLFNLRVFA NMTAARPNGS AHQAPSAFPG MPFVDEFARV SPWCRIDEPS DKVAASLMDY
APAGGFAVVR HPEDDDTLQL LVVVPPFGLT PYNILVDDDR VRLESTRYLC RDLSELVHIF
ASDNDEKAWL LNLETPTDDY LSRPWFSDTL TPDTAAALVE NQHVGSFVVF PSQFEDVFTL
VYVSTEGVVE KNILSRNEGY QLEGGSHQVF PTLTDLVNHY TFVRMNDLGT MLLQDPADFQ
ATHRHEHAPW FRPLMTRQDA EAVLAGLADG AFVVRKCEHN NATFALSYIF DGQVRHRLID
QDSEGITFFR ESTRAFKSLY ELVAAYSADH LDDIPCRLLN HIEAAQPPLS AASQQQQEAT
FAPDTTPAAA TTAQPAPLDP IYGHGSFPWL QLSPVTKAQA LASLAGKPDG AFVVRSSERA
PTFLSLSYVF GDHIYHELIG LLNAETDGDS GVYLLSVPDR IFETIYDLVT YYKLNAGELH
CPLVETDTAP APAFIRERAA WLVLGLPRDE AVSLLEGKPT GTFIIRESQS SSAHLVLCLV
DPTNTIVQEY IEMGDHGVYL EKNPDACFPT LHGLVQHYSQ PQPELPCPLV VYDTPLWAAS
TRSLSDTFVS ARPRQEERLT LESQHAASMR ARTRPELFRD DDARFFVQHA DDRSAELTAM
RSDRTLKWRS FTDNTLPLVG TVQSSREMRR HQQQQQQQRH QKHTHRRTRQ HHANGSRTFD
DNLFGNREDA VKRTCRQLGL YTDPTSQSWM CIKQPLADVR HLLRHQGDFV VHKSAHGNYA
CLTMQHEGNA VSFEMVRRNG GLGLLDSRET FDRLTRLIEH YVHPAQTDLP ASLGPNSM
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