ID F2TYH8_SALR5 Unreviewed; 697 AA.
AC F2TYH8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_01630 {ECO:0000313|EMBL:EGD78652.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832957; EGD78652.1; -; Genomic_DNA.
DR RefSeq; XP_004997610.1; XM_004997553.1.
DR AlphaFoldDB; F2TYH8; -.
DR STRING; 946362.F2TYH8; -.
DR EnsemblProtists; EGD78652; EGD78652; PTSG_01630.
DR GeneID; 16078206; -.
DR KEGG; sre:PTSG_01630; -.
DR eggNOG; KOG3564; Eukaryota.
DR InParanoid; F2TYH8; -.
DR OMA; ICHAECE; -.
DR OrthoDB; 22770at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199:SF3; FI24033P1-RELATED; 1.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 400..449
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 460..649
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 135..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 78..130
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 135..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78057 MW; A876AD91276B6423 CRC64;
MKGTVTQFDE LTHRLDTFVE AEQRRCRQLK KAVITFAPML DGKDTKAVLA TVGGKKVKWQ
PKRCASRLHQ LSVQKQHLNE QEKTLQTHIA NMREYLKELR ARYEEEAAIR EEAEHQAADM
MGEMERIRQL LYEDSDGSTT DSSSPHESPV PTTRSKLTRN SALRQSLLKV FESPTGRRVS
GRPPKYSPSP AQLAVERSPA KSMKTPSPAK RTSPNPRPAH ISPSMDKENA PQHMLGEAHS
PKRANTSPSP TRPAPAAEQV QTQHSNVQQL KQRFEHTRHS PQPHGSLAPQ APTSPPRRSY
APSPLRVMQS PGNTPTTPKH KQHWKPTVFA QCTQTSPARP SAPPSPTRGS PSPIKSPPPK
MALSPGEDRY NPTNTSSRVA SAPMSPTYQS PMPSARRALP HFFHTHTAFL RQACQQCHGT
ILYLNKYRKC STCGFICHAE CEESCPLDCG VLPTNRAHRQ SLDLLTATGP GYDIPKLLTS
CFQCIEERWL HAQGLYRHAG SSYEHKGVDL IHRFLRGRSE PNLRCINDPH EITTCVKLFL
SDLGEPLLTS RRHDNFVHAI VHNSGDKKLD AITAVVETLP RVNFFTLKCI IDHLNKVTAH
ASYNNATRDV LVVEMTPCLM RLRHNKGNQA MKPEEEVVDT LLALKQSHWR RAEKTVLECH
ARNPGERAPV SSHSSVKSSS SSGSSVRSPF RSWFSRR
//
