ID F2TZE5_SALR5 Unreviewed; 3959 AA.
AC F2TZE5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_11806 {ECO:0000313|EMBL:EGD78969.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CRELD family.
CC {ECO:0000256|ARBA:ARBA00005897}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GL832957; EGD78969.1; -; Genomic_DNA.
DR RefSeq; XP_004997925.1; XM_004997868.1.
DR STRING; 946362.F2TZE5; -.
DR EnsemblProtists; EGD78969; EGD78969; PTSG_11806.
DR GeneID; 16078520; -.
DR KEGG; sre:PTSG_11806; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR InParanoid; F2TZE5; -.
DR OMA; SICAAHE; -.
DR OrthoDB; 2899485at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00064; FU; 1.
DR Gene3D; 1.10.1330.10; Dockerin domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 13.
DR InterPro; IPR036439; Dockerin_dom_sf.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR46330:SF6; HEMATOPOIETIC DEATH RECEPTOR ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM01411; Ephrin_rec_like; 6.
DR SMART; SM00261; FU; 4.
DR SMART; SM00208; TNFR; 31.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 10.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REPEAT 23..70
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 23..70
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 189..228
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 189..228
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 445..488
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 445..488
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 493..536
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 493..536
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 541..584
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 541..584
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 961..1005
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 961..1005
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1010..1053
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 1010..1053
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1224..1264
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 1224..1264
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 1390..1434
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1390..1434
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 1463..1507
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 1463..1507
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 3265..3303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 3650..3694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3743..3959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3773..3788
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 52..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 467..480
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 470..488
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 515..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 518..536
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 563..576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 566..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 1032..1045
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 1035..1053
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 1486..1499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 1489..1507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 3274..3291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3293..3302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3959 AA; 414107 MW; 819D3A4AB4D28732 CRC64;
MCTTWRRRRN KGTSNPVCTQ CSPCAEGDSF EVSACSATAD TQCQSCTTSS DCDLNQYLSQ
PCTLSTDGVC TRCTQVGDCD SGFYLDGVCT ETQDASCQPC HPSCTECEDG TAQGCTACPE
TLALDRIGFG NVGSCVSSCP PGQAEDVAAN TCENCDSSCA TCSAPGDATK CTSCTGVLFL
TPSGTCSSSC PAGMYGNATT NTCVSCTACD TSSSYESSPC GGTDNRVCSD LTMCPPGTHV
IQQPTATSDR RCGDCGEGTY QPASNQAICI VWAECHPQEQ YESVAPTSTS NRVCTDLTEC
TPGAEFQLTA PTETSDRVCK ALTTCKANQW QSMAPTATTD RQCTNLTVCA ATEYQSMAPT
DTSDRQCEPI TQCQAHEYEK TAATPFSDAV CEAIRNCTQN EYQTQAPTAT SNRACAPLTT
CDFETQYIST PATPTSNRVC SALRSCFQHE FESQPPTTTT NRACTECAMC GSTQYERADC
TANTNRVCED LTQCKASQFE AVLATLTSDR ECSNCTVCGD NSYTVSPCSN VADTVCDGCT
TCPMGSFAAA ACTATSDTDC QACATCDAGF FVSSPCTQGS NTQCTRCTTC QPDEYQQVAC
SASADALCQT ITNCTQSQYQ VSAPTATTNR VCSAVRECTA GQEYETQAPT ATSNRACAPL
TTCDFETQFE SQAPTATSNR VCTPLSSCDA ETQYETQAPT QTSDRECEGL ATCVAGEFVA
TQPTPTSNRV CASCPAGTTD HDSDSETACV ACPAGHFSSA GSIGPCSLYM CPAGTADTDN
SASTPCEACD GTSSFQPAAG QAACLQATTC VAGEEEQDAP TAVSNRECRP CQLGVTYKAQ
PGQNTTCAAV RTCLAGEEQT LAPTLSSNRV CTTCGPGTFK AAAGQAHGLA SPPRTCAPGF
QESVVPTPAS DRQCEACPTG TFKSTTGQAT CTAHATCDTD TQYQTKAPTT STNRECGPLT
DCGTGEWEER APTATSDRVC ELCDSCEDEG LTQATACTET ANTVCENCDT CSPGFFVSSP
CTSVSQTECM ECAECGADQY QTQECRVSTN TQCTPLTTCT ASQYETVAPT DTSDRECAAL
TTCVVGQYEC VVPTETSNRQ CCAIAQCDVG EEEAVAPTAT SNRQCQNCTA GTTDDDANGA
TPCVQCPAGT FVPEGRTGDC SAYRCAPGTV DADQLPSTAC TPCSSGVSFA PTSGLTACVA
VSDCPAGEEE SVQPTLSSDR VCTVCAAGTF KEDAGQDDCM TASTCASGTQ YVAQPHTPTS
NTVCANVTQC TATQYQTVAP TTMSDRQCRN LTVCEANEYE TRAPTATTDR QCATVRAACS
MDEFESAAPT ATSDRECTQL TTCRAQQYEA RAPTPSTDRE CIYWTNCTAA QFQVTAPTSV
SDRVCANLTV CTATQFEAVA PTTTTNRVCE ACTDCPGGTH YEMTPCTASA DATCAMCSTC
SGDTYASAAC SETDDTTCTA CTQCVDGSTF ESSPCLAHDD RVCLPCTVCN VTEYIEQTCS
ATSDTQCLPY TTCDLDQFES QEPTRFQDRV CTQHTMCTPD VQYEIVAPTA TTDRQCDDLS
TCTAQQYIST AHTATSDRVC SALRQCTSSE FELVAPTTTS NRVCQRLTVC DPETEYESVP
AGPARDRVCA PLTVCSPLEY ESVAPTPTSN RQCEEQVLPP LSPLAIFSAS GGLALTSETT
YAESTSAQTA VLLQGTTNGE EGTGPVFSAS VGEASTSASL ETTRPAPAAV RFELAAAGTI
YEDDPWVRGV LQVSTPANVV PRATAMDVTV RLDAENATSV SCTTNAHGLC SFALRVPRGW
YTPGVDATAN VTFAFQEAAL QGAVAVQGQS SRLVTLASSA VFVPDNDVYV RLPNRDVRAG
ETLELEVLSR TAFPIASFAA VVTTSDDSRL RVNSLGLDFA SWTGTSKAPS TTSAAVLGIA
SASARLSGPA GGDQLLFTIS VSVPASATPG QASIDIILHS LDNAKGEGIR PGDRALPARV
VFVDRQGADA TNQGVVTVSG AQSQSIFAAP VSTLLAYTPT ISGVAALHHV ELFTMRESGG
LEALDAADVT CSSSHPAVVD VTPTCHLKLG ASSDLNAYAA TITVTLDADA GVTTAFDVRV
LRPALPVQLT VDDAELNAVT GWLDESSNCR QLYQKTRVRA FTSFSDDSGL VVDNIDVTKY
VTMHVSNDGV ATLSTPTHAG HDFAGVYVQG FQPGTVQVST TVQGLASSVS VVVSSTPVVA
TRLDITPVVS LGFSPALPSE LASQAALAAT LQVSSTFTAT NQHAPVGASV VLSDATRLEL
TAADGVRLVS DDAEVIEVQG LALVVRSQVQ TASVPVLDAS WSSGACAAQP IISRAVPVSL
SLPTVASIAA STERTVLAAP DSAAAAAPFM HASSTPVLLT ATLTGGARLD LDETDSLDIV
SPSELAVTET STGLLVTVAS GAAPGVYHAM VTYETASTNI SISVVDVAAL HVTCRLHANG
HTSQAEAGVV ASLAPFQGLS PATFQACAVD VRGVLSTDGG ATAVQTTDDV AASATISAVS
GALAVTGTIV SVASPTSPVL GQAAVDVSVV GVTTQLTLTV SSTPVSVASA TLTFPSQLRG
LAQTTSVTPE AAVTFSDSSV FDSAAVLPAG LVEFMLEEPA PLGATGASAS LLSAATGEVR
LLGNSVERLS LFLVTVDATS PVVLAEASFA CNLLPAEGEV DFGVNSGLAL SGATAGSLLS
FEVRANAGSA DIDRLVFDVL FNASLVDFVT AGAGSDFVGA VNAFSSTLPQ EEQAAFATHF
VRVTAEPNAG VSGVPHIATI TFTVKADTAD EQVFFAGRVA AFTSRAGGAI AVGASESTPI
VSPAASISTV IEAPSVMNRR RRRRRRDVAT TACPTPPCAV CPNGDTHQTG DVNADCVFTL
DDVTFFMDAY LETLLDPNYF STLLPVQQEQ LDADQDGTIG VLDVDLLSRV LSKDVRFVRD
VMVQPVDTSN GCRLEVAVRV FGAGNVPALP GSTHVFFDVE SMSAGFDTLF DASVVEVGQR
INVDKGSSSL QGGLWQAAHL GGDVYGVVVR TPIASEDMHG ITVFQLTSVN TTSGSGGFVG
VSTDALSFTW SGPRVPPFNF AGYDFELTVP TMPPFQFVRT AGYNPFATFT NEQATASCHA
TTSCTASEYE TAAPTATSSA ECMPISTCDA EEYETEAPTA TTDRECVNRT VCNVPVEYQS
SAGNATADRT CTNVTVCLEG EIALLEPTPT SDRVCRLDAP CDYNMYESVP LTLTTDRVCL
PVSECDPGFE ETAAPTATSD RECSLIDYCA NDPCQNNATC VSSTQLLTFV CNCPPGFTGT
MCEYADACGL LGDQNPCAPG SQCVNDAGGI RCECALGQAC GCCDGFTFLS CSLQTLPDTG
SYCSDPATVA EDLDNLQSRQ QQQSSATGES LGIIVGGVLG GLALLVLAVL AVTSLRRRSR
DKSEALVKYE QDPFSGMLTS MRNPVFAPAS QYLAAFKRVV CFSFLRYNKD LVLTEPAEEL
GTVYDILMVP RPPKRTLPTL KDDTNMFMEA KVSENERSLD EVVDFLSLAL ADLVMEEAID
TAAKEQSNGT RPYRANVPND ASGLIPKRWA AYLDPITGQV EEPAYEDASL LRGEFEDDEF
AVDGSVSPLT FAQAERFLAR RVTMRKSQMQ RGGARDNAFV YDMGAFSGDD DNDETYSTAN
MGDEPERMYD VGSSDGFGEP VYDEGDGEGG VQDTYAFASN PAALDDLEDF ADEEATYDMA
DADTQNAVRR GKSKKEIEAM YSRANKASVR EPNYDNAAPG MPGEHDDDDY DSANNLGLSD
EEEDGGPDYD NTLPSGTYDV RTMLTSGLND DGDDDGAEPQ YLGGNGSRRR GSEPEPVYDQ
GDGDVLGALP SFDEPDYDLG NEAPGAEESG ERDPAYDMAT AEGDSAGDTT GLMNTDPDYD
IGDAPAQEEE GLVSELFDDE EEHEPTYAFS QPRNTSVRPR ALRSLHGRTR PESLDGSSI
//
