ID F2UDN1_SALR5 Unreviewed; 1147 AA.
AC F2UDN1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RUN domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTSG_06089 {ECO:0000313|EMBL:EGD74726.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
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DR EMBL; GL832969; EGD74726.1; -; Genomic_DNA.
DR RefSeq; XP_004992983.1; XM_004992926.1.
DR AlphaFoldDB; F2UDN1; -.
DR STRING; 946362.F2UDN1; -.
DR EnsemblProtists; EGD74726; EGD74726; PTSG_06089.
DR GeneID; 16073556; -.
DR KEGG; sre:PTSG_06089; -.
DR eggNOG; KOG1808; Eukaryota.
DR eggNOG; KOG1829; Eukaryota.
DR InParanoid; F2UDN1; -.
DR OMA; HVLNCDL; -.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 53..179
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 826..877
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 201..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..236
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..764
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 126776 MW; 1A8513472908D6AA CRC64;
MEFGRWLDRV KEKVAASSGE RVDDSAYANE KEAIFVEVKQ AVQSVSVAGD VAIRSTPESM
RLCSAIERVL CHGLKIPWHA GEPTFWRAAA VISHKDVVNE IKRLAHANSD AARVRAWIRL
ALNENALESY VHALLHDTSL MEDVYETYAY MRDEEQATKF ETLLAGLSFT TFQMSVDDSS
LDVAPTPRAA QQELVMMHSP PTPVKRAEQH QQHQQQQQRK KTKAKKKQKK KPKPPHSKKG
AEHERDTAKD AASDAHSHAT TAARNVHSCD GDGRDAGEDG GDGGEQRITV TGDERTADSD
AGDGGGGDGG DERGDVGSTH HLQGVNELGS PTHAHEQEGG EDEEETSAGE RGQDEETERG
QEEEAKEHHG KGEAKEQGRE DEEEQARAQP ETQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
QQQQQQQQQQ QQQHKGATAA ASDHTTSPAV NAGQSTGAVQ EVAVCDERDV SATESALTSD
GIATSVVTAQ QQRNQGEEEH SEVEAEAAKK EANEEHSEEV VERHQRKQDD NTSNQADLQQ
QQQQVRVDRD DNNNTGGAST ALTPTPLATT STDQADTSFD GFEIITHDDI DTPTPAAGLS
RHRHDHDPGA LISAGGGDSR LVDVPLALDI ESDATTTADN TPVEGRSAAG SFYRMFEEVM
MADDDNTNDD AHGAIPATAA TAATAVVQGR TYEDRHSLGS FTSATHSIGS TSHPHQHHQQ
HRPRDVSPLS TTSTHQRQHP QHHPQHHHQH HHHQQHHQHP HQQQQHQARH ASPSSSATMV
RSVSSPRQRT VSGKRRDHGV DEQLAHAVDV LVDEEPQSTV PFEHNGHEFY ILPKCAGDCA
VCSRPLKTAL KPSRRLRCCR CRMNVHKRCH TYVARPCVGG RADLARLTTA ICPDDGLCAQ
DYKCAGCGTH IGHQPLLAPP KLCDYTGQHY CSTCHHDQRA VTPARVVRSW QFADMPVCLQ
ASEVLAATHD LPLLEIRRLN PSLFRHVEDL RELAGFRATL AHMSSFLLTC RRLPEARILL
PLQGHRHFLD ADAEHMYSMR DLVALHAGKL LKVVEKCVQD CEEHITRRCV LCKSKGHVCR
VCHSDDTLFS FQPDTHKCAV CRCVFHHHCF HAAASGICPA CEHRRQLKDR QRSTSTSGSS
AVKSSNA
//
