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Database: UniProt
Entry: F2US09_SALR5
LinkDB: F2US09_SALR5
Original site: F2US09_SALR5 
ID   F2US09_SALR5            Unreviewed;      2061 AA.
AC   F2US09;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN   ORFNames=PTSG_11059 {ECO:0000313|EMBL:EGD80414.1};
OS   Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX   NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN   [1] {ECO:0000313|Proteomes:UP000007799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Salpingoeca rosetta.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR   EMBL; GL832993; EGD80414.1; -; Genomic_DNA.
DR   RefSeq; XP_004987978.1; XM_004987921.1.
DR   STRING; 946362.F2US09; -.
DR   EnsemblProtists; EGD80414; EGD80414; PTSG_11059.
DR   GeneID; 16068505; -.
DR   KEGG; sre:PTSG_11059; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   InParanoid; F2US09; -.
DR   OrthoDB; 2659618at2759; -.
DR   Proteomes; UP000007799; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 2.
DR   CDD; cd00192; PTKc; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   PANTHER; PTHR24416:SF611; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000313|EMBL:EGD80414.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:EGD80414.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..2061
FT                   /note="receptor protein-tyrosine kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003288795"
FT   TRANSMEM        1565..1586
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1357..1460
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1461..1553
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1650..1915
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          485..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1927..1956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1987..2011
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        850..866
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1993..2011
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1681
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   2061 AA;  216251 MW;  DE378EE3F0ACD47C CRC64;
     MSAPAKPAMA PTRLLLLVVV VLALVGVSAQ DVVAVVAAED GAHTPPPPLI WPCSQDAATA
     VGTTTALWLT GSTIQACRDP STGGGDTCCS VDSYPADSFN NLTAPIVWHN GRLQPLPSTR
     TSAVCFASSL PCTGGLNETT AIFAVAPYQS DRSFVTAAQL RQVTAQALAS NTLVAFVHRD
     GSDAATLRTS LTTPDAIGPV LAADTAALEV TTQALDLASD LDGSLHTSGY ISTSAVATPS
     SLLLQITLAL PPNLSPAAVG ALQNSSVRVN TSVFVDGFLA VQGPLTFTPS VASSSSSSPS
     MLLRLVSTNI AATLPQYLFS RVRIDARMDL ASSAFPRVLL PTSAANVTVS VLAGNLRPLT
     LARTATVVWF PNSTNCSEIS NNGQQQQPQQ VPVFWNVPVG VCSPVPADPS THMHVTVTRA
     NVTVRVYDDD DTCSSPAVLE ASLPRHEATA SVFVSPPSPA AQQRHLPFCL AGAASSLLFA
     GLDPASAASN SSSNNNDDDT DNTNDDGLSE SISYATITPM TAFAAAQTVV AQIHRPGDLR
     VPIAGESTGE LTVPVVPRPS RLPTNGGGGG GDLWFVGARA DLEAAAGGSN PPITLRSQIM
     TVTAPVRVAG VHAVHVRGTC LHGTATVCFT GPVVDVVVPC QPGSDTLRWH YHVATVNVLP
     SDVRAGQASF TMRMCQTRML FDTIAISPLY SLGPLNTAAA TTSIPSSSEA ETSATNSTMC
     TASWPAAVCS QRGCRYDERR RLCHHRNAHA CWFVAESACT PDIGCAWSAT ISACINDDGD
     YAGGVVDSPL PFTSPIAVDV TAGGSGVYET VRVPVAWHTG ETRAFVLYPS HHAALPHIML
     VYGLAPSSSS PSPSPSPSPS PSPSPSSSSD SPAWAEWRAV SGVTAAALLQ SNAFLDTGVI
     AAATHRIPAP SDASPLLPAP LHANLQVTCS LLPVVSVTGD TASDEEISAT RAAVAVRVLD
     VTASTIRVQL SVPFATTTAP WPLAFTASPP AAAVHAAPTA QAHDPTAVLS TSVTATTTEA
     GATVLTAEVT GLSPATPYRI GVSASLCGAL TLANDDDNGN DGSSDRIAGR VVTATTLPST
     GPAPPPLLPL TASNRVEQLG WRLSSEGLHV SWFVHGQPPT DEYDAVLTHG STQQTITVAA
     NALDLSSALL SHESFDAATG TMRTPVSVNS LRAGRCATAT CQDGGHCTVP VYSEPHRQSV
     LFPYTGAFQP TMALQVRLRR GQQLLHEASA TVTGAAGVPA APTSLGATAG VDLLVVEWAP
     VPGAVDYELQ ANVTATNAPI SIISPTTLVR LPSLPRETPV SVRVRARARV ASGATAGLAC
     QRALGDVCAG NAAALVLAGP WSAAVTTRTL GNPPQAEPGA VRVVSLTDTT ATVAVDVLPG
     DPRALVVYAI TERTRANGAR EQETVRAVPT RVDEESGRLI ARVAGLSPFT TYAFRAAFVS
     AYGEGPMTAE ASTQNRTLRG VPGAPSLRNL RETGDGLLVQ WSAPGQEAGP IDFYTVYFTN
     IDNGTEVSMR VQEAGLLLQG LVPGSTYTVT VTASTPAGES ERSRVLTHTL LAAASSSGSS
     VSNGALAGIA VAVVLIVAVA MVVLLLHSRR QQRAAGQRLE LQLQHMKLNA DQLADQVRVM
     FSQEFAETIG GDLAQTEEDF ARLEVDRTRL QLGSELGKGA FGVVYRGTLT LNGQAQTVAV
     KTLLDGVVQD ELTKFLVEAR LMSLLRHDNL LRLVAVCTRD TPFYLVTEFM PKGDLKRFLR
     DCRPTRPEPR ERLTTAQLNR MVLQIASAMQ YLESRRVIHR DLAARNVLVN DNNVVKIADF
     GMSRNTEESD YYKKRSDDRV PIKWMAPESV TDRIYTSRSD VWSFGVLTWE VYSFARAPYA
     EYTAMEAVAA AAAGYRLPRP DMCPEGMYTV MQLCWAYGSQ DRPSFAVLAH EIDFFLRTGR
     FKALVQAEST QTKRGADSRR HHHPAPSTAI GSGGGGYDNV GSHTGYFGER EVAPVAVDAT
     GYVADASLDG NDADSGSGGT VTYPRLEPNT PAATTLYAET PARRRQHEPP YPRTVPNTQG
     GMVQNAAYQR LPNLHGQSPA P
//
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