ID F2VM67_9SAUR Unreviewed; 341 AA.
AC F2VM67;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=V(D)J recombination-activating protein 1 {ECO:0000256|ARBA:ARBA00021277};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN Name=RAG-1 {ECO:0000313|EMBL:ADZ14227.1};
OS Saltuarius swaini.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Pygopoidea; Carphodactylidae;
OC Saltuarius.
OX NCBI_TaxID=522452 {ECO:0000313|EMBL:ADZ14227.1};
RN [1] {ECO:0000313|EMBL:ADZ14227.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AMS 163012 {ECO:0000313|EMBL:ADZ14227.1};
RX PubMed=21184833; DOI=10.1016/j.ympev.2010.12.007;
RA Nielsen S.V., Bauer A.M., Jackman T.R., Hitchmough R.A., Daugherty C.H.;
RT "New Zealand geckos (Diplodactylidae): Cryptic diversity in a post-
RT Gondwanan lineage with trans-Tasman affinities.";
RL Mol. Phylogenet. Evol. 59:1-22(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; GU459541; ADZ14227.1; -; Genomic_DNA.
DR AlphaFoldDB; F2VM67; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0033151; P:V(D)J recombination; IEA:InterPro.
DR CDD; cd16530; RING-HC_RAG1; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR024627; RAG1.
DR InterPro; IPR035714; RAG1_imp-bd.
DR InterPro; IPR019485; RAG1_Znf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11539:SF0; V(D)J RECOMBINATION-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR11539; VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1; 1.
DR Pfam; PF12560; RAG1_imp_bd; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF10426; zf-RAG1; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51765; ZF_RAG1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01101}.
FT DOMAIN 254..293
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 315..341
FT /note="RAG1-type"
FT /evidence="ECO:0000259|PROSITE:PS51765"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ14227.1"
FT NON_TER 341
FT /evidence="ECO:0000313|EMBL:ADZ14227.1"
SQ SEQUENCE 341 AA; 38903 MW; 6F1F0A220EE4AE76 CRC64;
SIPEESHPAN NDTGKVAASL DKVSEKQADA MALMQESFQT GEKLNNGIQT IDKDAFCANQ
REIETHQVNL QQLCRICGGS FKNDPYKRSH PVHGPVDDEM QALLRKKERR ATSWPELLVK
VFKTDVRGDI DTIHPTNFCH NCWKVIQRKF SSTPCEVYFP RKGTMEWRPH SMSCDVCGTS
SRGMKRKKQA LNPQVSKKLR VIAERARKIM YTRSQKPVNS KSLMKKITNC KKIHLSTNML
TVDYPADFVK SISCQICEHI LADPVETTCK HLFCRLCILK CLKVIGSYCP SCRYPCFPTD
LMNPVRSFLN VMNTLVVRCP TKDCHEDVAL GKYSHHLSRH K
//
