ID F2Y7D0_MOSMO Unreviewed; 202 AA.
AC F2Y7D0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN Name=SCN8A {ECO:0000313|EMBL:ADZ73865.1};
OS Moschus moschiferus (Siberian musk deer) (Moschus sibiricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Moschidae;
OC Moschus.
OX NCBI_TaxID=68415 {ECO:0000313|EMBL:ADZ73865.1};
RN [1] {ECO:0000313|EMBL:ADZ73865.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21315162; DOI=10.1016/j.ympev.2011.02.009;
RA Zhou X., Xu S., Yang Y., Zhou K., Yang G.;
RT "Phylogenomic analyses and improved resolution of Cetartiodactyla.";
RL Mol. Phylogenet. Evol. 61:255-264(2011).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361132};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361132}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; HQ826417; ADZ73865.1; -; Genomic_DNA.
DR AlphaFoldDB; F2Y7D0; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR PANTHER; PTHR10037:SF23; SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:ADZ73865.1};
KW Ion transport {ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Sodium {ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132}; Transport {ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..119
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ73865.1"
FT NON_TER 202
FT /evidence="ECO:0000313|EMBL:ADZ73865.1"
SQ SEQUENCE 202 AA; 22818 MW; 75E005D52E07D40E CRC64;
LFLVMFIFSI FGMSNFAYVK HEAGIDDMFN FETFGNSMIC LFQITTSAGW DGLLLPILNR
PPDCNLDKEH PGSGFKGDCG NPSVGIFFFV SYIIISFLIV VNMYIAIILE NFSVATEESA
DPLSEDDFET FYEIWEKFDP DATQFIEYCK LADFADALEH PLRVPKPNTI ELIAMDLPMV
SGDRIHCLDI LFAFTKRVLG DS
//
