ID F3KKI7_9ARCH Unreviewed; 310 AA.
AC F3KKI7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain-containing protein {ECO:0000313|EMBL:EGG42116.1};
GN ORFNames=Nlim_1006 {ECO:0000313|EMBL:EGG42116.1};
OS Candidatus Nitrosarchaeum limnium SFB1.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC Nitrosopumilaceae; Nitrosarchaeum.
OX NCBI_TaxID=886738 {ECO:0000313|EMBL:EGG42116.1};
RN [1] {ECO:0000313|EMBL:EGG42116.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SFB1 {ECO:0000313|EMBL:EGG42116.1};
RX PubMed=21364937; DOI=10.1371/journal.pone.0016626;
RA Blainey P.C., Mosier A.C., Potanina A., Francis C.A., Quake S.R.;
RT "Genome of a low-salinity ammonia-oxidizing archaeon determined by single-
RT cell and metagenomic analysis.";
RL PLoS ONE 6:E16626-E16626(2011).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG42116.1}.
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DR EMBL; AEGP01000037; EGG42116.1; -; Genomic_DNA.
DR AlphaFoldDB; F3KKI7; -.
DR STRING; 886738.Nlim_1006; -.
DR PATRIC; fig|886738.10.peg.1112; -.
DR HOGENOM; CLU_019796_1_3_2; -.
DR Proteomes; UP000004348; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05303; PGDH_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 7..308
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 109..284
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 310 AA; 33751 MW; 7272DC18F4C9D981 CRC64;
MGFEDSVLIC DEVDPVLNKI LQDNGLKVSY EPKITPEQIK EKISNFNIVI VRSRTTITRE
IIEKADKCKI IARVGVGLDN VDQVAAKEKN IRVINAAEGA MNAVAELVLG LMLSLARQTA
RGDRAIRNGQ WLKNELKGTE LRGKYLGIVG LGNIGKRLGR LARALNMNII GYDVVPIDEE
FSKEVGLMKA DLDTLLQSSD YISIHVPLLD STYHLINAQK ISTMKKTAKI INTSRGGVVD
EDALYDALKS GNLGGAALDV FEKEPATGNK LAELDNVILT PHIGAQTKEA QSLAANITGE
KIIQILRGVI
//
