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Database: UniProt
Entry: F3NEP9_9ACTN
LinkDB: F3NEP9_9ACTN
Original site: F3NEP9_9ACTN 
ID   F3NEP9_9ACTN            Unreviewed;       623 AA.
AC   F3NEP9;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Acetolactate synthase {ECO:0000313|EMBL:EGG48033.1};
GN   ORFNames=SGM_1613 {ECO:0000313|EMBL:EGG48033.1};
OS   Streptomyces griseoaurantiacus M045.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX   NCBI_TaxID=996637 {ECO:0000313|EMBL:EGG48033.1, ECO:0000313|Proteomes:UP000003022};
RN   [1] {ECO:0000313|EMBL:EGG48033.1, ECO:0000313|Proteomes:UP000003022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M045 {ECO:0000313|EMBL:EGG48033.1,
RC   ECO:0000313|Proteomes:UP000003022};
RX   PubMed=21551298; DOI=10.1128/JB.05053-11;
RA   Li F., Jiang P., Zheng H., Wang S., Zhao G., Qin S., Liu Z.;
RT   "Draft genome sequence of the marine bacterium Streptomyces
RT   griseoaurantiacus M045, which produces novel manumycin-type antibiotics
RT   with a pABA core component.";
RL   J. Bacteriol. 193:3417-3418(2011).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGG48033.1}.
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DR   EMBL; AEYX01000027; EGG48033.1; -; Genomic_DNA.
DR   RefSeq; WP_006139218.1; NZ_AEYX01000027.1.
DR   AlphaFoldDB; F3NEP9; -.
DR   STRING; 996637.SGM_1613; -.
DR   eggNOG; COG3962; Bacteria.
DR   Proteomes; UP000003022; Unassembled WGS sequence.
DR   GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   CDD; cd02003; TPP_IolD; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR030817; Myo_inos_IolD.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR   PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003022};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          10..126
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          223..356
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          419..576
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   623 AA;  66616 MW;  831BEB9DCA4F302F CRC64;
     MSPSPRVRLT VAQALVRFLS AQYTERDGAR HRLIAGTWGV FGHGNVAGVG QALLEYADAM
     PYHQGRNEQA MVHAAVGYAR QLNRLSAQAV TTSIGPGATN LVTGAALATI NRLPVLLLPG
     DHFATRPADP LLQQLEHPSG ADITVNDALR PVSRFFDRIT RPEALLASAL QAMRVLTDPA
     ETGAVTLALP QDVQAEAYDW PEEFFAERVW HVRRPEPDPA ELAEAVRLLR GARRPLLVAG
     GGVHHSEAEE ALKALVDVTG IPVASTQAGK GSLRHDHPAD LGGIGHTGTA VADALAREAD
     LVLGVGTRYS DFTTASGTLF QHPDVRFVNL NITAFDAHKL AARPLLADAR SGLTALTAAL
     ADHRVDAAYE AEYRAGKERW ERVVAAAFDA EDDAVPTQTQ VLGALDAVVG DTDVVINAAG
     SLPGDLHKLW RARSPRQYHL EYGYSCMGYE IPAAVGVQQA APEVVVWSLV GDGTYLMMPT
     EIVTAVQEGL PVNLVLLQNH GYASIGGLSE ETGGERFGTA YRYRAADGSF TGDPLPVDLA
     ANAASLGMDV LRAKTVRELR EALTAARASD RPTCVYVETD PAATAPPAEA WWDVPVAAVS
     GREAALAARE RYDRRVTARR HHL
//
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