ID F3NP08_9ACTN Unreviewed; 728 AA.
AC F3NP08;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Bi-domain oxidoreductase {ECO:0000313|EMBL:EGG44820.1};
GN ORFNames=SGM_4872 {ECO:0000313|EMBL:EGG44820.1};
OS Streptomyces griseoaurantiacus M045.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=996637 {ECO:0000313|EMBL:EGG44820.1, ECO:0000313|Proteomes:UP000003022};
RN [1] {ECO:0000313|EMBL:EGG44820.1, ECO:0000313|Proteomes:UP000003022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M045 {ECO:0000313|EMBL:EGG44820.1,
RC ECO:0000313|Proteomes:UP000003022};
RX PubMed=21551298; DOI=10.1128/JB.05053-11;
RA Li F., Jiang P., Zheng H., Wang S., Zhao G., Qin S., Liu Z.;
RT "Draft genome sequence of the marine bacterium Streptomyces
RT griseoaurantiacus M045, which produces novel manumycin-type antibiotics
RT with a pABA core component.";
RL J. Bacteriol. 193:3417-3418(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG44820.1}.
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DR EMBL; AEYX01000042; EGG44820.1; -; Genomic_DNA.
DR RefSeq; WP_006142702.1; NZ_AEYX01000042.1.
DR AlphaFoldDB; F3NP08; -.
DR STRING; 996637.SGM_4872; -.
DR eggNOG; COG0673; Bacteria.
DR eggNOG; COG1063; Bacteria.
DR Proteomes; UP000003022; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08255; 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43350:SF19; D-GULOSIDE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000003022}.
FT DOMAIN 50..367
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 728 AA; 76922 MW; F0BF741804E1AD38 CRC64;
MKQVVQNYKS GELTLLDVPV PGCKPGGVLV RTLYSLISTG TELMKVSEAG MSMLGKARSR
PDQVAKVVQS VAVNGVPATY RKVMGKLDSY TPLGYSLCGV VEEVGAGIDD VKVGDLVACA
GNEHALHAEV NWVPKNLYAP VPDGLAPRHA AFGTVGSIAL QGVRQGESRL GEVALVVGLG
LIGQLVAQLL TASGVRVIGA DPDPARCELA ERLGAAACGD PSSPAVENAV AELTDGHGVD
QVYLAAGGGS NQPVELAARL SRDRGRVVDI GKCRLDLPWN AYYEKELDVR FSRSYGPGRY
DPEYELEGRD YPIGHVRWTE RRNLACFLDL VARGRVDVEP LVSHVAEFED AVEAYRRLEE
GELKAVAVLF RYPDHTAETV PPEVGVPAVR RAAAAPAPVR AAGRPVRLAF LGAGNYATSM
LLPHLAGREG VELSAVVTTT ALSAANAQRK FGFAEATTDL DAVLGDASVD AVFVVTRHSS
HAELTRKALL AGKAVFVEKP LALTEEELAG VLAAVEESGN DRLQVGFNRR FAPLLVEAGK
RFGPRSGPAS LRCLINAGRL DPGSWYLRQS TEGSRFAGEG GHFIDTASRL LGADPVSVYA
RATPGNEDLQ VVLGYPDGST ATLSYVTSGP SGFPKETLDL VADGRALRLD DFVRASVYDG
RRRTWVSSRL PKARDKGQEA ELAAFVRAVR TGGPMPVPLE SQATTTAATL AVAASLAAGA
PVTLTGAR
//