ID F3SJ14_STRSA Unreviewed; 757 AA.
AC F3SJ14;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=ATP-dependent Clp protease {ECO:0000313|EMBL:EGG39717.1};
GN Name=clpE {ECO:0000313|EMBL:EGG39717.1};
GN ORFNames=HMPREF9397_1136 {ECO:0000313|EMBL:EGG39717.1};
OS Streptococcus sanguinis SK1087.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888824 {ECO:0000313|EMBL:EGG39717.1, ECO:0000313|Proteomes:UP000003378};
RN [1] {ECO:0000313|EMBL:EGG39717.1, ECO:0000313|Proteomes:UP000003378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK1087 {ECO:0000313|EMBL:EGG39717.1,
RC ECO:0000313|Proteomes:UP000003378};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG39717.1}.
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DR EMBL; AFDP01000015; EGG39717.1; -; Genomic_DNA.
DR RefSeq; WP_002919439.1; NZ_GL883609.1.
DR AlphaFoldDB; F3SJ14; -.
DR PATRIC; fig|888824.3.peg.1115; -.
DR HOGENOM; CLU_005070_4_0_9; -.
DR Proteomes; UP000003378; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:EGG39717.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EGG39717.1}.
FT DOMAIN 366..401
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 59..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83774 MW; 60EE6EB9558F348A CRC64;
MLCQNCKINE STIHLYTNVN GHKQQVDLCQ NCYQIMKTDP EHSLFGGIAN ANNHGTDPID
DFFNSLSNFQ QPQEPTTPPT QSGGAAYGGG GGYGSNPSKG GQPQPSPQRP KGLLEEFGIN
VTELARRGEI DPVIGRDEEI VRVIEILNRR TKNNPVLIGE PGVGKTAVVE GLAQKIVDGD
VPHKLQGKEV IRLDVVSLVQ GTGIRGQFEE RMQKLIDEIR SRQDVILFID EIHEIVGAGS
AGDGNMDAGN ILKPALARGE LQMVGATTLN EYRIIEKDAA LERRMQPVKV DEPTVEETII
ILKGIQKKYE DYHHVKYTDA AIEAAALLSN RYIQDRFLPD KAIDLLDEAG SKMNLTLNFV
DSKVIDQRLI EAENLKAQAT RDEDFEKAAY FRDQIAKYKE LQQTSVLDKD TPIISEKTIE
HIVEQKTNIP VGDLKEKEQS QLVNLASDLK AHVIGQDDAV DKIAKAIRRN RVGLGSPNRP
IGSFLFVGPT GVGKTELSKQ LAIELFGSAD SMIRFDMSEY MEKHSVAKLV GAPPGYVGYD
EAGQLTERVR RNPYSLILLD EVEKAHPDVM HMFLQVLDDG RLTDGQGRTV SFKDTIIIMT
SNAGTGKAEA SVGFGAAREG RTNSVLGELG NFFSPEFMNR FDGIIEFQAL SKDNLLQIVN
LMLDDVNQRL ATNDIHLDVT EKVKEKLVDL GYDPKMGARP LRRTIQDHIE DAITDFYLEN
PSEKELKAIM TSNGKILIKS AKKTESTESV NSSQEEK
//
