ID F3U9F0_STRSA Unreviewed; 1178 AA.
AC F3U9F0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894,
GN ECO:0000313|EMBL:EGJ40255.1};
GN ORFNames=HMPREF9393_0253 {ECO:0000313|EMBL:EGJ40255.1};
OS Streptococcus sanguinis SK1056.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888820 {ECO:0000313|EMBL:EGJ40255.1, ECO:0000313|Proteomes:UP000004171};
RN [1] {ECO:0000313|EMBL:EGJ40255.1, ECO:0000313|Proteomes:UP000004171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK1056 {ECO:0000313|EMBL:EGJ40255.1,
RC ECO:0000313|Proteomes:UP000004171};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGJ40255.1}.
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DR EMBL; AFFL01000001; EGJ40255.1; -; Genomic_DNA.
DR RefSeq; WP_002920736.1; NZ_GL890990.1.
DR AlphaFoldDB; F3U9F0; -.
DR PATRIC; fig|888820.3.peg.254; -.
DR HOGENOM; CLU_001042_2_2_9; -.
DR Proteomes; UP000004171; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Cell cycle {ECO:0000313|EMBL:EGJ40255.1};
KW Cell division {ECO:0000313|EMBL:EGJ40255.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01894}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894}.
FT DOMAIN 518..637
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 167..482
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 674..939
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1178 AA; 132670 MW; 5E8A8AD76BEC7A46 CRC64;
MFLKEIEIQG FKSFADKTKV VFDQGVTAVV GPNGSGKSNI TESLRWALGE SSVKSLRGGK
MPDVIFAGTE TRKPLNYASV VVVLDNSDQF IKDAANEIRV ERHIYRSGDS EYKIDGKKVR
LRDVHDLFMD TGLGRDSFSI ISQGKVEEIF NSKPEERRAI FEEAAGVLKY KTRRKETENK
LSQTQDNLDR LEDIIYELES QVKPLEKQAE TAKRFLSLDG QRRELYLDVL VAQLTANKER
LTQAEEDLRN IQQELAAYYS KRDELEVENQ TLKAKRHELN QTLSDDQASL LELTRLISDL
ERQIDLSKLE SSQAATSRRE NEERLAALSE KLAQIESNIE DKQAELSKIA AKLADNEESI
AALEAELEDF SDDPDQLIEH LREQYVKLMQ EEANLSNDLT SLESQLASEL KLAESKKADY
AKLQGDLEAS QTQEQAGLEE LEIARQALKG LLADYQSQIQ LVEKLEADYK HQQTKMFELL
DDLKNKQARS NSLEAILKNH SNFYAGVKSV LQEAGRLGGI VGAVSEKLGF DPHYQTALEI
ALGASSQNII VEDEAAATRA IEFLKKNRAG RATFLPLTTI KPRQLPDHNR ATIEKSAGFL
GLASSLVSYE SSLDSIFQNL LGTTAIFDTV EHARAAARQV RYQVRMVTLD GTELRTGGSY
AGGANRNNNT IFIKPELDAL LEEIKQKNIS LKEQEEAVQI LQNQLSQAKQ VLEQIKTDGE
QARLAEQKAN LAYEQLAKRV EELTSLKNLQ EQELAGQSAL DISEEKDRLQ TRLTEIEQEK
ADITAEIEQV KSNKDAVQAR FDKLSSRLAE LKLQRTELTS NQRFEKNDLE RLSEEKASLE
KEQATLELLM EQKEQSSLQK VDITILEEQL ETAKQEKIEL DQRLIRLKFE LEDLEGQSDD
IASRLEQARH QNEELIRRQA KAEAEKDKLM DVMRRLASNL TDDYQISFEE ASSQARPLES
LPAAESQVKD LEKAIRALGP VNLEAVEQFE EVSNRLSFLN EQRDDVLSAK NLLLETIEEM
NDEVKERFKS TFEAIRESFK VTFRQMFGGG SADLILTEGD LLTAGVEISV QPPGKKIQSL
NLMSGGEKAL SALALLFSII RVKTIPFVIL DEVEAALDEA NVKRFGDYLN RFDKDSQFIV
VTHRKGTMSA ADSIYGVTMQ ESGVSKIVSV KLKDLESM
//
