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Database: UniProt
Entry: F3Z758_9ACTN
LinkDB: F3Z758_9ACTN
Original site: F3Z758_9ACTN 
ID   F3Z758_9ACTN            Unreviewed;       699 AA.
AC   F3Z758;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   05-JUL-2017, entry version 42.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=STTU_3224 {ECO:0000313|EMBL:EGJ76013.1};
OS   Streptomyces sp. Tu6071.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=355249 {ECO:0000313|EMBL:EGJ76013.1, ECO:0000313|Proteomes:UP000003955};
RN   [1] {ECO:0000313|Proteomes:UP000003955}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21705604; DOI=10.1128/JB.00377-11;
RA   Erxleben A., Wunsch-Palasis J., Gruning B.A., Luzhetska M.,
RA   Bechthold A., Gunther S.;
RT   "Genome sequence of Streptomyces sp. strain Tu6071.";
RL   J. Bacteriol. 193:4278-4279(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CM001165; EGJ76013.1; -; Genomic_DNA.
DR   RefSeq; WP_007824503.1; NZ_CM001165.1.
DR   EnsemblBacteria; EGJ76013; EGJ76013; STTU_3224.
DR   Proteomes; UP000003955; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003955};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003955}.
FT   DOMAIN      392    520       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      606    675       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     400    407       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   699 AA;  78485 MW;  84FB533649E646C9 CRC64;
     MADVPADLAA VWPRVVDQLL GEGPDSRAPG VEGKDEHWVR RCQPLALVAD TALLAVPNEF
     AKTVLEGRLA PVVSETLSRE CGRPIRIAIT VDESMGDAPA PPRYEEPVQV PRPRFEEPGQ
     PRYETQERYE PIEAQTLYEP PIERGPHVRP VYHEYQAPGS WPRVHEDYGW QQQRLGYTES
     EAYGQGGRGD YRQAPAERSP YEKQDGREGR DERYEQPDRP ERPERPERPE RFDAGDRYES
     GERYEPGERY ESGERYEQER PSSPYEQQRG TYEKPGARGG YGRGYEEQRP REEPRGYEEH
     GAGEQRERGD EAARPGPGRQ RGPVPLPSQG GPSLAPSGAP GPLAAQPAPA AGPGEPTARL
     NPKYLFDTFV IGASNRFAHA AAVAVAEAPA KAYNPLFIYG ESGLGKTHLL HAIGHYARSL
     YPGTRVRYVS SEEFTNEFIN SIRDGKGDSF RKRYREMDIL LVDDIQFLAD KESTQEEFFH
     TFNTLHNANK QIVLSSDRPP RQLVTLEDRL RNRFEWGLTT DVQPPELETR IAILRKKAVQ
     EQLNAPPEVL EFIASRISRN IRELEGALIR VTAFASLNRQ PVDLGLTEIV LKDLIPGGED
     ASPEITASAI MSATADYFGQ TVEDLCGSSR SRVLVTARQI AMYLCRELTD LSLPKIGAQF
     GGRDHTTVMH ADRKIRALMA ERRSIYNQVT ELTNRIKNG
//
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