ID   F3Z916_9ACTN            Unreviewed;       273 AA.
AC   F3Z916;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:EGJ73634.1};
GN   ORFNames=STTU_0845 {ECO:0000313|EMBL:EGJ73634.1};
OS   Streptomyces sp. Tu6071.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=355249 {ECO:0000313|EMBL:EGJ73634.1};
RN   [1] {ECO:0000313|EMBL:EGJ73634.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tu6071 {ECO:0000313|EMBL:EGJ73634.1};
RA   Erxleben A., Wunsch-Palasis J., Gruening B.A., Luzhetska M., Bechthold A.,
RA   Gunther S.;
RT   "Genome sequence of Streptomyces sp. Tu6071.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CM001165; EGJ73634.1; -; Genomic_DNA.
DR   AlphaFoldDB; F3Z916; -.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   Proteomes; UP000003955; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
FT   DOMAIN          16..261
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        49
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         107
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            74
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   273 AA;  29991 MW;  CE9696B57F5BA943 CRC64;
     MVPPIVLNNG VEMPQLGFGV WQVPDEEATT AVGLALDAGY RSIDTAAIYG NERGTGKALA
     ASGLAREELF VTTKLWNEEQ GYDSTLRAFD ASLDKLGLDY VDLYLIHWPC PSKDRYVDTW
     RAFEKLLADG RTRAIGVSNF TPAHLERLIG ETSVIPAVNQ IELHPHLQQS ESRAFHGEQG
     IATEAWSPLG QGKGLLEVPA LVAIAQKHGR TPAQVVLRWH VQLGNVVIPK SVTPSRIKEN
     IDVFSFELDE EDMAAIRALN EEHRLGGHPD EVG
//