ID F3ZZK2_MAHA5 Unreviewed; 789 AA.
AC F3ZZK2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:AEE96828.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AEE96828.1};
GN OrderedLocusNames=Mahau_1647 {ECO:0000313|EMBL:AEE96828.1};
OS Mahella australiensis (strain DSM 15567 / CIP 107919 / 50-1 BON).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family IV. Incertae Sedis; Mahella.
OX NCBI_TaxID=697281 {ECO:0000313|EMBL:AEE96828.1, ECO:0000313|Proteomes:UP000008457};
RN [1] {ECO:0000313|Proteomes:UP000008457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15567 / CIP 107919 / 50-1 BON
RC {ECO:0000313|Proteomes:UP000008457};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Teshima H., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Pukall R.,
RA Steenblock K., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Mahella australiensis DSM 15567.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEE96828.1, ECO:0000313|Proteomes:UP000008457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15567 / CIP 107919 / 50-1 BON
RC {ECO:0000313|Proteomes:UP000008457};
RX PubMed=21886860;
RA Sikorski J., Teshima H., Nolan M., Lucas S., Hammon N., Deshpande S.,
RA Cheng J.F., Pitluck S., Liolios K., Pagani I., Ivanova N., Huntemann M.,
RA Mavromatis K., Ovchinikova G., Pati A., Tapia R., Han C., Goodwin L.,
RA Chen A., Palaniappan K., Land M., Hauser L., Ngatchou-Djao O.D., Rohde M.,
RA Pukall R., Spring S., Abt B., Goker M., Detter J.C., Woyke T., Bristow J.,
RA Markowitz V., Hugenholtz P., Eisen J.A., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Mahella australiensis type strain (50-1
RT BON).";
RL Stand. Genomic Sci. 4:331-341(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP002360; AEE96828.1; -; Genomic_DNA.
DR RefSeq; WP_013781256.1; NC_015520.1.
DR AlphaFoldDB; F3ZZK2; -.
DR STRING; 697281.Mahau_1647; -.
DR KEGG; mas:Mahau_1647; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_1_9; -.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000008457; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:AEE96828.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008457};
KW Transferase {ECO:0000313|EMBL:AEE96828.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..316
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 368..535
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 596..775
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 789 AA; 87774 MW; C93BABACB89C52FB CRC64;
MKNANLKLSK KEEEKKQRKA LKWRYTAFVM AFIVMFSALL YRLADLQIVN GADYLHQSET
NKMRPIKIEA PRGKILDRNM QVMAANERRY VVEMYRHNLI DEAINDVLTK TLAILEKNGD
GFIDNLPIVL TNKGFAFNWD TDDAEKAKAK EAKFKNDNNI EASASAEEAF KALREKYKIP
EDMDVQQARK IVAIRYEMSQ SGYKRYIPTP IAINVSQKTV FEIEEHSVEL PGVNISTQYV
RQYPMGQTAA HVVGYLGKIS EEEKDKYEAK GYDISKALVG KSGIEKSMED QLTGSSGDRL
GERWVMTDVV GRLIKELPDK AKDPKSGNNV VLNIDAELQK VAEQSLKNTI DAIRNGKYNK
PGPYADDGAA VVMNVNTGEV LAMVSYPSYD PNGMVGNNAA KYFRQLISDE SNPLLNRVIT
GAYTPGSTFK IATAVAALQE GVVTPNTIIV DKGLYTLNDT LNPKDAPACW YWNDHGKTHG
PEDVRDAIKD SCNYYFFEVT NRMGIDNLYK WADRLGLTRP TGIDLPGEIS SFVDNPGRRE
AATRTFITNN IKKALNVEEM NAEWEQRINA TVDKLLKVKY YDKTSVRAIL DEDLHLGDDN
TLVDTLTSSR GTWATQQWSI IDHIITGIGQ AQTMLTPIAI VRYISAVVNG GKVMTPHVVK
QVVDNNGTVI ETIQPEVQDD LKLDPAYVEA IKAGMHSVTE EGGTASSFFG QFLKQYPSMS
VGGKTGTAQT SNDPKKSNAV FVAFAPYEKP EIAIAIVVPG GRSGSYLSPV AIDILKTYFK
LDRTEEAKP
//
