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Database: UniProt
Entry: F4BXY1_METCG
LinkDB: F4BXY1_METCG
Original site: F4BXY1_METCG 
ID   F4BXY1_METCG            Unreviewed;       559 AA.
AC   F4BXY1;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   Name=mcrA {ECO:0000313|EMBL:AEB67565.1};
GN   OrderedLocusNames=MCON_0759 {ECO:0000313|EMBL:AEB67565.1};
OS   Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC
OS   103675 / OCM 69 / GP-6) (Methanothrix concilii).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosaetaceae; Methanosaeta.
OX   NCBI_TaxID=990316 {ECO:0000313|EMBL:AEB67565.1, ECO:0000313|Proteomes:UP000007807};
RN   [1] {ECO:0000313|EMBL:AEB67565.1, ECO:0000313|Proteomes:UP000007807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6
RC   {ECO:0000313|Proteomes:UP000007807};
RX   PubMed=21571998; DOI=10.1128/JB.05031-11;
RA   Barber R.D., Zhang L., Harnack M., Olson M.V., Kaul R.,
RA   Ingram-Smith C., Smith K.S.;
RT   "Complete genome sequence of Methanosaeta concilii, a specialist in
RT   aceticlastic methanogenesis.";
RL   J. Bacteriol. 193:3668-3669(2011).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP002565; AEB67565.1; -; Genomic_DNA.
DR   RefSeq; WP_013718622.1; NC_015416.1.
DR   SMR; F4BXY1; -.
DR   STRING; 990316.MCON_0759; -.
DR   EnsemblBacteria; AEB67565; AEB67565; MCON_0759.
DR   GeneID; 10460472; -.
DR   KEGG; mcj:MCON_0759; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000007807; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007807};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000007807};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:AEB67565.1}.
FT   DOMAIN        7    276       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      324    450       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       155    155       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     265    265       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     279    279       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   559 AA;  61305 MW;  78F415D6EC730C31 CRC64;
     MAVKHTKKLF VKALNKKFGK DFDLASQKVE YKRLGPEQNA RKREFMEYAK KLEGKRGMTG
     YNPYVHAGGI PLGQRQLVPY KLSSTEYVVE GDDLHFVNNP AMQQFWDDIR RTIVVGLDMA
     HEVLQKRLGK EVTPETINNY LEILNHAMPG AAVVQEHMVE THPGLVDDCN VRVFSGDDAL
     ADEIDDQYKI DINKMFPEDQ AETLKAAIGK TTWQAIHVPT IVVRTCDGGT TSRWSAMQLC
     MTFIDAYNMC AGEAAVADLA YAAKHAAVLQ MSDMLPARRA RGPNNPGGIS FGFMSDMVQT
     SRVKPQDPVY VSLNVVAAGS MFYDQIWLGS YMSGGVGFTQ YATAAYTNDV LDDFSYYGVD
     YANDKFGGFA KAPATIDVAK ELATEVTLYG IEQYEAFPTL LEDHFGGSQR AAVLAAASGI
     TSAIATGHSQ IGLAGWYLSM LLHKEAWGRL GFFGYDLQDQ CGPTNVFSYQ SDEGNPLELR
     GANYPNYAMN VGHQGEYAGI TSAAHAGRMD AFAVNPLIKV TFANPGLVFD FANVRDCFGK
     GGAREFRAAG ERSLVMPAV
//
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