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Database: UniProt
Entry: F4C184_SPHS2
LinkDB: F4C184_SPHS2
Original site: F4C184_SPHS2 
ID   F4C184_SPHS2            Unreviewed;       510 AA.
AC   F4C184;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723543};
DE            EC=3.1.11.6 {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723538};
GN   OrderedLocusNames=Sph21_1456 {ECO:0000313|EMBL:ADZ78018.1};
OS   Sphingobacterium sp. (strain 21).
OC   Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Sphingobacterium.
OX   NCBI_TaxID=743722 {ECO:0000313|EMBL:ADZ78018.1, ECO:0000313|Proteomes:UP000007808};
RN   [1] {ECO:0000313|Proteomes:UP000007808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=21 {ECO:0000313|Proteomes:UP000007808};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I.,
RA   Siebers A.K., Allgaier M., Thelen M.P., Hugenholtz P., Woyke T.;
RT   "Complete sequence of Sphingobacterium sp. 21.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides.
CC       {ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family.
CC       {ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP002584; ADZ78018.1; -; Genomic_DNA.
DR   RefSeq; WP_013664746.1; NC_015277.1.
DR   STRING; 743722.Sph21_1456; -.
DR   EnsemblBacteria; ADZ78018; ADZ78018; Sph21_1456.
DR   KEGG; shg:Sph21_1456; -.
DR   PATRIC; fig|743722.3.peg.1561; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   OrthoDB; POG091H02EK; -.
DR   BioCyc; SSP743722:GH04-1445-MONOMER; -.
DR   Proteomes; UP000007808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007808};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723511, ECO:0000313|EMBL:ADZ78018.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|RuleBase:RU004355,
KW   ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007808}.
FT   DOMAIN       11    117       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      142    500       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   510 AA;  58261 MW;  B80C11452B3684F5 CRC64;
     MPEIIADKTI FSLAEVARSI QKTIADRYKS LYWIKAEMNK LNHYSHSGHC YPELLEKQEG
     KVIAEIRATL WKSDYERINQ RFVEIIKEPL KNGINILLQA SISYDPVHGL SLHIVDIDPS
     YSLGELEREK QASIALLKEE GLFEANKLLP FPLLPKRIAI VSVETSKGLA DFLKIIDHNS
     FGYRFEYELF PALLQGEKSV ISIIDQLAKI RLQLQRFDVV AIIRGGGGEV GLSSYNNVLL
     AKAIATFPIP VITGIGHATN ETVSELVAYK NAITPSALAD YLLQHFHNFA RPVTYAEQVL
     RLKTRQLFDN QQQLLNNNIR YFRMASLNML HENKHQLANL RNRTLQQSKY QLIQEKGSFQ
     RLKSQLSTQS KRTLMEEKQA ITFLGQRLKR ENLHLSKRSR QVIRQIRDQL IRQSHQIAKK
     HHAALTTLHK NLAPGIKRLL VEATKSLDNQ ERHLSILDPQ HVLKRGYSIM LFQGKAVTDA
     QVLKVGDKVK TILAFGETDS QVTFVNEIKK
//
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