ID F4CZ08_PSEUX Unreviewed; 321 AA.
AC F4CZ08;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:AEA24299.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:AEA24299.1};
GN OrderedLocusNames=Psed_2074 {ECO:0000313|EMBL:AEA24299.1};
OS Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 /
OS CB1190).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=675635 {ECO:0000313|EMBL:AEA24299.1, ECO:0000313|Proteomes:UP000007809};
RN [1] {ECO:0000313|EMBL:AEA24299.1, ECO:0000313|Proteomes:UP000007809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55486 / DSM 44775 / JCM 13855 / CB1190
RC {ECO:0000313|Proteomes:UP000007809};
RX PubMed=21725009; DOI=10.1128/JB.00415-11;
RA Sales C.M., Mahendra S., Grostern A., Parales R.E., Goodwin L.A., Woyke T.,
RA Nolan M., Lapidus A., Chertkov O., Ovchinnikova G., Sczyrba A.,
RA Alvarez-Cohen L.;
RT "Genome sequence of the 1,4-dioxane-degrading Pseudonocardia dioxanivorans
RT strain CB1190.";
RL J. Bacteriol. 193:4549-4550(2011).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP002593; AEA24299.1; -; Genomic_DNA.
DR AlphaFoldDB; F4CZ08; -.
DR STRING; 675635.Psed_2074; -.
DR KEGG; pdx:Psed_2074; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_11; -.
DR Proteomes; UP000007809; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AEA24299.1}; Pyruvate {ECO:0000313|EMBL:AEA24299.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007809}.
FT DOMAIN 15..305
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 321 AA; 33120 MW; 95235D35371B7B6D CRC64;
MTVSADQALD LYRVMATIRV FETTAGSLFA AGELPGFIHL SSGQEAVAAG VCSVLRRDDA
LTTTHRGHGH CIAKGGKVFG MLAELYGRAA GYGKGRSGSM HIADSSAGIL GANAIVGGGL
PMALGAAWSA QVRGEDRVAV AFFGDGAVAE GVFHETLNLA ALWRLPLVLV CENNRVAEMT
PSSVHLATTR VADFAGPYAI PGATVDGNDV LVVRDAAATA VARARAGEGP TLLECETHRI
RGHFEGDPLR YRSAEETAAW AARDPLVLFR ARLAELGVPS ARVEAVDTEV AAEVRDAAAA
AAAAAPAPVS SLLDDVRPGV S
//
