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Database: UniProt
Entry: F4D245_PSEUX
LinkDB: F4D245_PSEUX
Original site: F4D245_PSEUX 
ID   F4D245_PSEUX            Unreviewed;       555 AA.
AC   F4D245;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   25-OCT-2017, entry version 49.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Psed_0001 {ECO:0000313|EMBL:AEA22286.1};
OS   Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM
OS   13855 / CB1190).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Pseudonocardia.
OX   NCBI_TaxID=675635 {ECO:0000313|EMBL:AEA22286.1, ECO:0000313|Proteomes:UP000007809};
RN   [1] {ECO:0000313|EMBL:AEA22286.1, ECO:0000313|Proteomes:UP000007809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55486 / DSM 44775 / JCM 13855 / CB1190
RC   {ECO:0000313|Proteomes:UP000007809};
RX   PubMed=21725009; DOI=10.1128/JB.00415-11;
RA   Sales C.M., Mahendra S., Grostern A., Parales R.E., Goodwin L.A.,
RA   Woyke T., Nolan M., Lapidus A., Chertkov O., Ovchinnikova G.,
RA   Sczyrba A., Alvarez-Cohen L.;
RT   "Genome sequence of the 1,4-dioxane-degrading Pseudonocardia
RT   dioxanivorans strain CB1190.";
RL   J. Bacteriol. 193:4549-4550(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002593; AEA22286.1; -; Genomic_DNA.
DR   RefSeq; WP_013672228.1; NC_015312.1.
DR   STRING; 675635.Psed_0001; -.
DR   EnsemblBacteria; AEA22286; AEA22286; Psed_0001.
DR   KEGG; pdx:Psed_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; ATHIERN; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000007809; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007809};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007809}.
FT   DOMAIN      247    375       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      459    528       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     255    262       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   555 AA;  60287 MW;  8FDAFBA0AA7BA69C CRC64;
     MTDQPGDLGA VWNRVIGDLS GSSGDGDTPP LSAQQRAFLR LTRPLGLLDG TALLAAPSEF
     AKDAIERILR KPISDALGRH LGVQVNLAVV VDASAASGGT EVPDPPDPRA AARVAPAERS
     AGPSGLAASV DVVGDAEPLS ANGSHSDLGS LGEAAPIDDS AGRFRSGPAA AQADLLPPPA
     SGIPGPDSRP GQDGWPTYSA PAPDAPPAAR SRSMLNEKYT FDTFVIGASN RFSHAAAVAV
     AEAPARAYNP LFIWGESGLG KTHLLHAVGH YAQRLFPGMR VRYVSTEEFT NDFINSLRDD
     RKVAFQRRYR DVDVLLVDDV QFLEGKEGTQ EEFFHTFNTL HNSNKQIVVS SDRPPKRLET
     LEDRMRTRFE WGLITDIQPP ELETRIAILR KKAAQDRLAV PGDVLEFIAA RIERNIRELE
     GALIRVTAFA SLNRQPVDTQ LAEIVLRDLI PDSAASEITA PTIMAVTAEF FDVTMDELCG
     PGKTKALAQA RQIAMYLCRE LTDLSLPRIG QTFGGRDHTT VMHADKKIRN EISLRRKTFE
     QVQELTARIK QRARH
//
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