ID F4FXV9_METCR Unreviewed; 156 AA.
AC F4FXV9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Riboflavin synthase {ECO:0000256|ARBA:ARBA00013950, ECO:0000256|PIRNR:PIRNR015750};
DE EC=2.5.1.9 {ECO:0000256|ARBA:ARBA00012827, ECO:0000256|PIRNR:PIRNR015750};
GN OrderedLocusNames=Mcup_0046 {ECO:0000313|EMBL:AEB94157.1};
OS Metallosphaera cuprina (strain Ar-4).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=1006006 {ECO:0000313|EMBL:AEB94157.1, ECO:0000313|Proteomes:UP000007812};
RN [1] {ECO:0000313|EMBL:AEB94157.1, ECO:0000313|Proteomes:UP000007812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ar-4 {ECO:0000313|EMBL:AEB94157.1,
RC ECO:0000313|Proteomes:UP000007812};
RX PubMed=21551305; DOI=10.1128/JB.05038-11;
RA Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.;
RT "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-
RT oxidizing archaeon from a hot spring.";
RL J. Bacteriol. 193:3387-3388(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC ChEBI:CHEBI:58201; EC=2.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000968,
CC ECO:0000256|PIRNR:PIRNR015750};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}.
CC -!- SIMILARITY: Belongs to the DMRL synthase family.
CC {ECO:0000256|ARBA:ARBA00007424, ECO:0000256|PIRNR:PIRNR015750}.
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DR EMBL; CP002656; AEB94157.1; -; Genomic_DNA.
DR AlphaFoldDB; F4FXV9; -.
DR STRING; 1006006.Mcup_0046; -.
DR KEGG; mcn:Mcup_0046; -.
DR PATRIC; fig|1006006.8.peg.46; -.
DR eggNOG; arCOG01322; Archaea.
DR HOGENOM; CLU_1682776_0_0_2; -.
DR UniPathway; UPA00275; UER00405.
DR Proteomes; UP000007812; Chromosome.
DR GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR InterPro; IPR002180; LS/RS.
DR InterPro; IPR036467; LS/RS_sf.
DR InterPro; IPR006399; Ribfl_synth_arc.
DR NCBIfam; TIGR01506; ribC_arch; 1.
DR Pfam; PF00885; DMRL_synthase; 1.
DR PIRSF; PIRSF015750; Ribfl_synth_arc; 1.
DR SUPFAM; SSF52121; Lumazine synthase; 1.
PE 3: Inferred from homology;
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619,
KW ECO:0000256|PIRNR:PIRNR015750};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015750}.
SQ SEQUENCE 156 AA; 17033 MW; 1D894C712C8F2AE7 CRC64;
MIERIYGVAD TTFSRVNMGE IAIKVIRKED PDSQISRYTV PGIKDLPVAA KKLIDSGCNG
VITLGWVGKT QLDKYSYLAA SIGLIFVQIS TSRHVIDVTV HEDEAEDEET LREIAIDRAK
KHSVNLVKLI KDGGNALTEM AGKGLRQGYS NAGSID
//
