ID   F4HFL6_GALAU            Unreviewed;       288 AA.
AC   F4HFL6;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE            EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN   OrderedLocusNames=UMN179_01029 {ECO:0000313|EMBL:AEC17057.1};
OS   Gallibacterium anatis (strain UMN179) (Pasteurella anatis).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Gallibacterium.
OX   NCBI_TaxID=1005058 {ECO:0000313|EMBL:AEC17057.1, ECO:0000313|Proteomes:UP000006908};
RN   [1] {ECO:0000313|EMBL:AEC17057.1, ECO:0000313|Proteomes:UP000006908}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMN179 {ECO:0000313|EMBL:AEC17057.1,
RC   ECO:0000313|Proteomes:UP000006908};
RX   PubMed=21602325; DOI=10.1128/JB.05177-11;
RA   Johnson T.J., Fernandez-Alarcon C., Bojesen A.M., Nolan L.K., Trampel D.W.,
RA   Seemann T.;
RT   "Complete genome sequence of Gallibacterium anatis strain UMN179, isolated
RT   from a laying hen with peritonitis.";
RL   J. Bacteriol. 193:3676-3677(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC         Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC         Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR   EMBL; CP002667; AEC17057.1; -; Genomic_DNA.
DR   RefSeq; WP_013745843.1; NC_015460.1.
DR   AlphaFoldDB; F4HFL6; -.
DR   STRING; 1005058.UMN179_01029; -.
DR   MEROPS; C56.006; -.
DR   KEGG; gan:UMN179_01029; -.
DR   PATRIC; fig|1005058.3.peg.1016; -.
DR   eggNOG; COG0693; Bacteria.
DR   HOGENOM; CLU_066933_0_0_6; -.
DR   Proteomes; UP000006908; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036524; F:protein deglycase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002818; DJ-1/PfpI.
DR   InterPro; IPR017283; HchA.
DR   PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR   PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR   Pfam; PF01965; DJ-1_PfpI; 1.
DR   PIRSF; PIRSF037798; Chaperone_HchA; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT   DOMAIN          75..197
FT                   /note="DJ-1/PfpI"
FT                   /evidence="ECO:0000259|Pfam:PF01965"
SQ   SEQUENCE   288 AA;  31830 MW;  9D6339D7E8D0D0B1 CRC64;
     MTELSKKPVA DRAEHNAFFP SDYSLTQYTS KVTEFDGFKF DKSYSGDKHK VLMIATDERY
     IEMKNGKLFS TGNHPVEMLL PMLHMHHAGF EIDVATLSGN PVKLEIWAMP EEDKAVMDLY
     NQYLPKLVNP KKLADILPEV LSENSPYIAV FIPGGHGVLA GIPHSKEVKS VLNWALNQDK
     HIITLCHGPA SLLAASVDEK AEDYPFKGYE ICVFPDALDE GANQDIGYMP GKLQWLVAEN
     LEKLGVKVLN KGITGQVHKD RKLLTGDSPL ASNALGILAA EELLKTVA
//