ID F4IC69_ARATH Unreviewed; 842 AA.
AC F4IC69;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Disease resistance protein (CC-NBS-LRR class) family {ECO:0000313|EMBL:AEE28863.1};
GN OrderedLocusNames=At1g12290 {ECO:0000313|Araport:AT1G12290,
GN ECO:0000313|EMBL:AEE28863.1};
GN ORFNames=F5O11.3 {ECO:0000313|EMBL:AEE28863.1}, F5O11_3
GN {ECO:0000313|EMBL:AEE28863.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE28863.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AEE28863.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|EMBL:AEE28863.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AEE28863.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CP002684; AEE28863.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58532.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58533.1; -; Genomic_DNA.
DR RefSeq; NP_001318986.1; NM_001332028.1.
DR RefSeq; NP_001320959.1; NM_001332029.1.
DR RefSeq; NP_001320960.1; NM_001332030.1.
DR AlphaFoldDB; F4IC69; -.
DR SMR; F4IC69; -.
DR ProteomicsDB; 189890; -.
DR EnsemblPlants; AT1G12290.2; AT1G12290.2; AT1G12290.
DR EnsemblPlants; AT1G12290.3; AT1G12290.3; AT1G12290.
DR EnsemblPlants; AT1G12290.4; AT1G12290.4; AT1G12290.
DR GeneID; 837783; -.
DR Gramene; AT1G12290.2; AT1G12290.2; AT1G12290.
DR Gramene; AT1G12290.3; AT1G12290.3; AT1G12290.
DR Gramene; AT1G12290.4; AT1G12290.4; AT1G12290.
DR Araport; AT1G12290; -.
DR TAIR; AT1G12290; -.
DR HOGENOM; CLU_000427_4_0_1; -.
DR OMA; IMIERNT; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IC69; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR33463:SF190; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 117..359
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 842 AA; 95743 MW; 49E089AFAA8D3F94 CRC64;
MEDLKALRDD LLRKVQTAEE GGLQRLHQIK VWLKRVKTIE SQFNDLDSSR TVELQRLCCC
GVGSRNLRLS YDYGRRVFLM LNIVEDLKSK GIFEEVAHPA TRAVGEERPL QPTIVGQETI
LEKAWDHLMD DGTKIMGLYG MGGVGKTTLL TQINNRFCDT DDGVEIVIWV VVSGDLQIHK
IQKEIGEKIG FIGVEWNQKS ENQKAVDILN FLSKKRFVLL LDDIWKRVEL TEIGIPNPTS
ENGCKIAFTT RCQSVCASMG VHDPMEVRCL GADDAWDLFK KKVGDITLSS HPDIPEIARK
VAQACCGLPL ALNVIGETMA CKKTTQEWDR AVDVSTTYAA NFGAVKERIL PILKYSYDNL
ESESVKTCFL YCSLFPEDDL IEKERLIDYW ICEGFIDGDE NKKGAVGEGY EILGTLVCAS
LLVEGGKFNN KSYVKMHDVV REMALWIASD LRKHKDNCIV RAGFRLNEIP KVKDWKVVSR
MSLVNNRIKE IHGSPECPKL TTLFLQDNRH LVNISGEFFR SMPRLVVLDL SWNVNLSGLP
DQISELVSLR YLDLSYSSIG RLPVGLLKLK KLMHLNLESM LCLESVSGID HLSNLKTVRL
LNLRMWLTIS LLEELERLEN LEVLTIEIIS SSALEQLLCS HRLVRCLQKV SVKYLDEESV
RILTLPSIGD LREVFIGGCG MRDIIIERNT SLTSPCFPNL SKVLITGCNG LKDLTWLLFA
PNLTHLNVWN SRQIEEIISQ EKASTADIVP FRKLEYLHLW DLPELKSIYW NPLPFPCLNQ
INVQNKCRKL TKLPLDSQSC IVAGEELVIQ YGDEEWKERV EWEDKATRLR FLPSCKLVLC
NR
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