ID F4L0P8_HALH1 Unreviewed; 348 AA.
AC F4L0P8;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Proline-specific peptidase {ECO:0000313|EMBL:AEE49530.1};
DE EC=3.4.11.5 {ECO:0000313|EMBL:AEE49530.1};
GN OrderedLocusNames=Halhy_1641 {ECO:0000313|EMBL:AEE49530.1};
OS Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O).
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Haliscomenobacteraceae;
OC Haliscomenobacter.
OX NCBI_TaxID=760192 {ECO:0000313|EMBL:AEE49530.1, ECO:0000313|Proteomes:UP000008461};
RN [1] {ECO:0000313|EMBL:AEE49530.1, ECO:0000313|Proteomes:UP000008461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27775 / DSM 1100 / LMG 10767 / O
RC {ECO:0000313|Proteomes:UP000008461};
RX PubMed=21886862; DOI=10.4056/sigs.1964579;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Daligault H., Lapidus A., Zeytun A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Verbarg S., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Woyke T.;
RT "Complete genome sequence of Haliscomenobacter hydrossis type strain (O).";
RL Stand. Genomic Sci. 4:352-360(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 1100;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Pagani I.,
RA Daligault H., Detter J.C., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Verbarg S., Frueling A.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "Complete sequence of chromosome of Haliscomenobacter hydrossis DSM 1100.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S33 family.
CC {ECO:0000256|ARBA:ARBA00010088, ECO:0000256|PIRNR:PIRNR005539}.
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DR EMBL; CP002691; AEE49530.1; -; Genomic_DNA.
DR RefSeq; WP_013764084.1; NC_015510.1.
DR AlphaFoldDB; F4L0P8; -.
DR STRING; 760192.Halhy_1641; -.
DR GeneID; 78191556; -.
DR KEGG; hhy:Halhy_1641; -.
DR eggNOG; COG2267; Bacteria.
DR HOGENOM; CLU_020336_15_0_10; -.
DR Proteomes; UP000008461; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR002410; Peptidase_S33.
DR InterPro; IPR005945; Pro_imino_pep.
DR NCBIfam; TIGR01250; pro_imino_pep_2; 1.
DR PANTHER; PTHR43798; MONOACYLGLYCEROL LIPASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF005539; Pept_S33_TRI_F1; 1.
DR PRINTS; PR00793; PROAMNOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:AEE49530.1};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR005539, ECO:0000313|EMBL:AEE49530.1};
KW Protease {ECO:0000313|EMBL:AEE49530.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008461};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003317388"
FT DOMAIN 82..334
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 159
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
FT ACT_SITE 301
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
FT ACT_SITE 328
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005539-1"
SQ SEQUENCE 348 AA; 39667 MW; DA1AD426CEA13B91 CRC64;
MFNNQFALQS MPFLTFLLLL VAFTACQQTP PPPADHVHLE DYFSSPGPSP KSGGVRLIPI
KTPKGEFKVW TKRFGNNPKI KVLLLHGGPG GTHEYFESFE SFLPKEGIEF IYLDQLGSAY
SDNPADTSLW NLPRFVEELE QIRVSLDLNK DNFYLLGHSW GGILAMQYAL KYQDNIKGLI
VSNMMASCPK YGEYAEKVLS KLMDPKVLQE IRDIEARKDF SNPRYMELLV PNFYEKHILR
MPAAEWPDAA NRSFAKMNQQ IYVSMQGPSE FGISGKLEKW DVSAELPKIK TPTLVIAASH
DTMDPEYMEW MSTQFPNGQF VLCPNGGHMC MWDDQEHYFP GLIAFLKQ
//
