ID F4L484_HALH1 Unreviewed; 730 AA.
AC F4L484;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dipeptidyl-peptidase IV {ECO:0000313|EMBL:AEE50782.1};
DE EC=3.4.14.5 {ECO:0000313|EMBL:AEE50782.1};
GN OrderedLocusNames=Halhy_2918 {ECO:0000313|EMBL:AEE50782.1};
OS Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O).
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Haliscomenobacteraceae;
OC Haliscomenobacter.
OX NCBI_TaxID=760192 {ECO:0000313|EMBL:AEE50782.1, ECO:0000313|Proteomes:UP000008461};
RN [1] {ECO:0000313|EMBL:AEE50782.1, ECO:0000313|Proteomes:UP000008461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27775 / DSM 1100 / LMG 10767 / O
RC {ECO:0000313|Proteomes:UP000008461};
RX PubMed=21886862; DOI=10.4056/sigs.1964579;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Daligault H., Lapidus A., Zeytun A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Verbarg S., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Woyke T.;
RT "Complete genome sequence of Haliscomenobacter hydrossis type strain (O).";
RL Stand. Genomic Sci. 4:352-360(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 1100;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Pagani I.,
RA Daligault H., Detter J.C., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Verbarg S., Frueling A.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "Complete sequence of chromosome of Haliscomenobacter hydrossis DSM 1100.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; CP002691; AEE50782.1; -; Genomic_DNA.
DR RefSeq; WP_013765325.1; NC_015510.1.
DR AlphaFoldDB; F4L484; -.
DR STRING; 760192.Halhy_2918; -.
DR GeneID; 78192742; -.
DR KEGG; hhy:Halhy_2918; -.
DR eggNOG; COG0823; Bacteria.
DR eggNOG; COG1506; Bacteria.
DR HOGENOM; CLU_006105_2_0_10; -.
DR OrthoDB; 9812921at2; -.
DR Proteomes; UP000008461; Chromosome.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF200; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AEE50782.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008461};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 89..440
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 530..723
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 730 AA; 82418 MW; 8D98482A8DAAD2EE CRC64;
MNKFTLLISA VSQRVCIIVV LLALVNTNLV AQGGGNQWTK DGNAYWTNER GEIVQYTLPE
QTRSVIVDAA MLTPAGKNQA LRVRSFQLSK DNRKVLIYTN SVRVWRMDTR GDYWVLDLDK
KTLKQLGANL PVSSLMFAKF SPDGSKVAYV SKHNLYVENL ADSKTTQLTK DGTDKIINGT
FDWAYEEEFF CRDGFRWSPD GNNIAYWQID ATAVKYFLMM NTTDSIYSYT IPVEYPKVGE
TPSACRVGIV PVKGGATRWM NVPGDNRQHY IPRMSWAANA TEIVLQQLDR KQQVSKIFLC
NITNGTAKVI LEEKDEAWVD VHLDPNQDWD WINGGKEFLW LTEKDGWRHY YRVSRDGKQE
KLITAGNYDV IDPGMIDEKN NVVYFIASPD NATEKYLYKT NLDGSGKAER LSPANTQGTY
GYQFAPSGRF AQQRFSNVNT RPQSDWVSIS DCKPLKAKTE GVKTESVGPK VEFFQVTTAD
NVTMDGWVVK PTNFDPQKKY PVVFYVYTEP AGQTVNNSWG TGNANMYQGS MADDGYVYIS
LDNRGTPAPK GRAWRKSIYR KIGLVNIHDQ AMGAKEVFKW GYIDTSRVAV WGWSGGGSAT
LNLLFQHPEI YKAGFSVAAV ANQLCYDNIY QERYMGLPQE NMEDFVKGSP ITYAKNLKGK
LLYVHGTGDD NVHYQNAELL INELIKHNKQ FQMMAYPNRS HGISEGEGTS THLGTMFTKF
LRENCPPGGK
//
