ID F4MI66_9DIPT Unreviewed; 232 AA.
AC F4MI66;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
DE AltName: Full=GST class-theta {ECO:0000256|ARBA:ARBA00041523};
GN Name=GSTu1 {ECO:0000313|EMBL:ADK66970.1};
GN ORFNames=CHIRRI_LOCUS10472 {ECO:0000313|EMBL:CAG9807626.1};
OS Chironomus riparius.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Chironomus.
OX NCBI_TaxID=315576 {ECO:0000313|EMBL:ADK66970.1};
RN [1] {ECO:0000313|EMBL:ADK66970.1}
RP NUCLEOTIDE SEQUENCE.
RA Prakash M.G., Park S.Y., Choi J.H.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADK66970.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21276481; DOI=10.1016/j.aquatox.2010.12.006;
RA Nair P.M., Choi J.;
RT "Identification, characterization and expression profiles of Chironomus
RT riparius glutathione S-transferase (GST) genes in response to cadmium and
RT silver nanoparticles exposure.";
RL Aquat. Toxicol. 101:550-560(2011).
RN [3] {ECO:0000313|EMBL:CAG9807626.1}
RP NUCLEOTIDE SEQUENCE.
RA King R.;
RL Submitted (JAN-2022) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAG9807626.1}
RP NUCLEOTIDE SEQUENCE.
RG ENA_rothamsted_submissions;
RG culmorum;
RA King R.;
RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710};
CC -!- SIMILARITY: Belongs to the GST superfamily. Theta family.
CC {ECO:0000256|ARBA:ARBA00009899}.
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DR EMBL; EZ966128; ADK66970.1; -; mRNA.
DR EMBL; OU895879; CAG9807626.1; -; Genomic_DNA.
DR AlphaFoldDB; F4MI66; -.
DR Proteomes; UP001153620; Chromosome 3.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43969; GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR43969:SF7; GST-CONTAINING FLYWCH ZINC-FINGER PROTEIN; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP001153620};
KW Transferase {ECO:0000313|EMBL:ADK66970.1}.
FT DOMAIN 1..80
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 86..215
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 232 AA; 26807 MW; 2A6AE44F57EC172D CRC64;
MKLYVVDDGP PSLACRMTFK LLNIPFEQIE VNYNVGEHLT ETYAKLNPQK EIPVLDDNGF
LLSEHIAIMQ YICDKYAPDS QAYPKDPTLR ALVNHRLCFN MAHFYSAIAP YTLGTIYFEY
PRNAVGLKRV HMALEVFEEY LKRIGKKYVV ADHITIADFP LVTSMICLEG IAFPYDKFTR
VKTWYETFKR ENPELWAIAE GGLKVIQEIE KNPPDLSKLD HPIHPVRKTA KH
//
