ID F4N2U7_YEREN Unreviewed; 553 AA.
AC F4N2U7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=RNA polymerase sigma factor RpoD {ECO:0000256|HAMAP-Rule:MF_00963};
DE AltName: Full=Sigma-70 {ECO:0000256|HAMAP-Rule:MF_00963};
GN Name=rpoD {ECO:0000256|HAMAP-Rule:MF_00963,
GN ECO:0000313|EMBL:CBX72405.1};
GN ORFNames=YEW_HH31370 {ECO:0000313|EMBL:CBX72405.1};
OS Yersinia enterocolitica W22703.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=913028 {ECO:0000313|EMBL:CBX72405.1};
RN [1] {ECO:0000313|EMBL:CBX72405.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21453472; DOI=10.1186/1471-2164-12-168;
RA Fuchs T.M., Brandt K., Starke M., Rattei T.;
RT "Shotgun sequencing of Yersinia enterocolitica strain W22703 (biotype 2,
RT serotype O:9): genomic evidence for oscillation between invertebrates and
RT mammals.";
RL BMC Genomics 12:168-168(2011).
CC -!- FUNCTION: Sigma factors are initiation factors that promote the
CC attachment of RNA polymerase to specific initiation sites and are then
CC released. This sigma factor is the primary sigma factor during
CC exponential growth. {ECO:0000256|HAMAP-Rule:MF_00963}.
CC -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC {ECO:0000256|HAMAP-Rule:MF_00963}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00963}.
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00963}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00963}.
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DR EMBL; FR718690; CBX72405.1; -; Genomic_DNA.
DR AlphaFoldDB; F4N2U7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.601.10; RNA Polymerase Primary Sigma Factor; 1.
DR Gene3D; 1.10.220.120; Sigma-70 factor, region 1.1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00963; Sigma70_RpoD_SigA; 1.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR000943; RNA_pol_sigma70.
DR InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR007624; RNA_pol_sigma70_r3.
DR InterPro; IPR007631; RNA_pol_sigma_70_non-ess.
DR InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR InterPro; IPR042189; RNA_pol_sigma_70_r1_1_sf.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR028630; Sigma70_RpoD.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR30603; RNA POLYMERASE SIGMA FACTOR RPO; 1.
DR PANTHER; PTHR30603:SF47; RNA POLYMERASE SIGMA FACTOR SIGF, CHLOROPLASTIC; 1.
DR Pfam; PF04546; Sigma70_ner; 1.
DR Pfam; PF03979; Sigma70_r1_1; 1.
DR Pfam; PF00140; Sigma70_r1_2; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF04539; Sigma70_r3; 1.
DR PRINTS; PR00046; SIGMA70FCT.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
DR PROSITE; PS00715; SIGMA70_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00963};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00963};
KW Sigma factor {ECO:0000256|ARBA:ARBA00023082, ECO:0000256|HAMAP-
KW Rule:MF_00963}; Transcription {ECO:0000256|HAMAP-Rule:MF_00963};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00963}.
FT DOMAIN 445..458
FT /note="RNA polymerase sigma-70"
FT /evidence="ECO:0000259|PROSITE:PS00715"
FT REGION 214..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..491
FT /note="Sigma-70 factor domain-2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00963"
FT MOTIF 445..448
FT /note="Interaction with polymerase core subunit RpoC"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00963"
FT COMPBIAS 232..254
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 63324 MW; DA17D4BFD349E93D CRC64;
MWGQIPQYAV MAGSGDKKKP QMLLLAVSPT DTNPNTLKCG YRLMEQNPQS QLKLLVTRGK
EQGYLTYAEV NDHLPEDIVD SDQIEDIIQM INDMGIQVLE EAPDADDLML AENTTDTDDD
AAEAAAQVLS SVESEIGRTT DPVRMYMREM GTVELLTREG EIDIAKRIED GINQVQCSVA
EYPEAITYLL EQYDRVEAGE ARLSDLITGF VDPNAEEDIA PTATHVGSEL STEEMDDDDD
EDEDDEEEED DNSIDPELAR QKFSELREQY ENARLEIKKN GRSHANAAAE ILKLSEVFKQ
FRLVPKQFDY LVNNMRAMMD RVRTQERIIM KLCVEQCKMP KKNFVTLFAS NETSDTWFAA
AIAMGKPWSE KLKDVSDDVQ RSLQKLRQIE EETGLTIEQV KDINRRMSIG EAKARRAKKE
MVEANLRLVI SIAKKYTNRG LQFLDLIQEG NIGLMKAVDK FEYRRGYKFS TYATWWIRQA
ITRSIADQAR TIRIPVHMIE TINKLNRISR QMLQEMGREP TPEELAERML MPEDKIRKVL
KIAKEPISME PNR
//
